Simple action potential measurement of cardiac cell sheet utilizing electronic sheet
Simple action potential measurement of cardiac cell sheet utilizing electronic sheet
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DOI：
10.1007/s10015-018-0429-y
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发表时间：
2018-09-01
影响因子：
0.9
通讯作者：
Umezu, Shinjiro
中科院分区：
文献类型：
--
作者：
Ohya, Takashi;Nakazono, Kazuki;Umezu, Shinjiro
本研究研制了一种测量心肌细胞片动作电位的装置。动作电位的测量使用了一个由2 μ m厚的聚对二甲苯薄膜组成的装置，上面印着银电极，被称为电子片。聚对二甲苯薄膜具有较高的生物相容性和柔韧性。因此，它显示了生物医学微机电系统应用的前景。在这项研究中，使用了细胞片，因为它在再生医学中获得了兴趣，可以在体外创造与体内相似的心脏组织。将细胞片技术与柔性电子片技术相结合，可实现高效的药物开发系统。利用研制的柔性电子片测量了大鼠心肌细胞片的动作电位。
In this study, a device for measuring the action potential of cardiac cell sheets was developed. The action potential was measured using a device comprising a 2-mu m-thick parylene film with a silver electrode printed on it, which was referred to as the electronic sheet. The thin parylene film exhibits high biocompatibility and flexibility. Therefore, it demonstrates promise for biomedical microelectromechanical system applications. In this study, a cell sheet was used because the interest it had garnered in regenerative medicine for creating cardiac tissue in vitro similar to that in vivo. A high-efficiency drug development system can be realized by combining cell sheet technology and fabricating a flexible electronic sheet. The action potential of a cardiac cell sheet from a rat was measured using the as-developed flexible electronic sheet.