Changes in quantitative CT image features of ground-glass nodules in differentiating invasive pulmonary adenocarcinoma from benign and in situ lesions: histopathological comparisons
Changes in quantitative CT image features of ground-glass nodules in differentiating invasive pulmonary adenocarcinoma from benign and in situ lesions: histopathological comparisons
复制标题
磨玻璃结节定量 CT 图像特征的变化在区分侵袭性肺腺癌与良性和原位病变时的变化：组织病理学比较
DOI：
10.1016/j.crad.2017.12.011
复制
发表时间：
2018-05-01
影响因子：
2.6
通讯作者：
Xie, X. Q.
中科院分区：
文献类型：
--
作者：
Zhang, Y. P.;Heuvelmans, M. A.;Xie, X. Q.
目的：评估磨玻璃结节（GGNs）中非实性成分从基线到随访时定量CT特征的渐进性变化，以区分侵袭性（微浸润性腺癌[MIA]和浸润性腺癌[IA]）GGNs与良性或浸润前（原位腺癌[AIS]）病变。
材料与方法：本研究纳入在基线和随访计算机断层扫描（CT）中均检测到GGN且接受组织取样检查的患者。测量整个GGNs中非实性成分的直径、平均CT密度、最大CT密度、最小CT密度以及密度偏差。通过线性回归分析这些特征随时间的进展情况。采用逻辑回归模型创建联合测量指标，并进行多变量受试者工作特征分析，以评估对侵袭性GGNs的诊断效能。
结果：纳入61例患者（24例男性），共70个GGNs。其中15个GGNs为良性，6个为AIS，38个为MIA，11个为IA。从基线到随访，所有组织学亚型的平均直径均增加，MIA组增加幅度最大（p （此处p值相关内容似乎不完整） ）
AIM: To evaluate progressive changes in quantitative CT features of the non-solid component of ground-glass nodules (GGNs) from baseline to follow-up to differentiate invasive (minimally invasive adenocarcinoma [MIA] and invasive adenocarcinoma [IA]) GGNs from benign or pre-invasive (adenocarcinoma in situ [AIS]) lesions.MATERIALS AND METHODS: Patients with a GGN detected at baseline and follow-up computed tomography (CT), examined by tissue sampling were included in the study. The diameter and mean, maximum, minimum CT density and density deviation from the non-solid component of whole GGNs were measured. Progression of these features over time was analysed by linear regression analysis. Multivariate receiver operating characteristics analyses of combined measures created by a logistic regression model were performed to evaluate diagnostic performance for invasive GGNs.RESULTS: Sixty-one patients (24 males) with 70 GGNs were included. Fifteen GGNs were benign, six AIS, 38 MIA, and 11 IA. The mean diameter of all histological subtypes increased from baseline to follow-up, the largest increase was found in the MIA group (p