Ovarian atypical endometriosis: Its close association with malignant epithelial tumours
Ovarian atypical endometriosis: Its close association with malignant epithelial tumours
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DOI：
10.1046/j.1365-2559.1997.d01-592.x
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发表时间：
1997-03-01
期刊：
影响因子：
6.4
通讯作者：
Ushigome, S
中科院分区：
文献类型：
--
作者：
Fukunaga, M;Nomura, K;Ushigome, S
本文研究了1987年至1995年期间卵巢非典型子宫内膜异位症的发病率及其与恶性上皮肿瘤的关系。255例卵巢子宫内膜异位症患者中有4例（1.7%）出现不典型腺体改变，1例卵巢不典型子宫内膜异位症患者随后发生腹壁子宫内膜样癌。224例卵巢癌中伴有卵巢子宫内膜异位症的54例（24.1%）；21例为典型，33例为非典型子宫内膜异位症。透明细胞癌和子宫内膜样癌最常与子宫内膜异位症相关，分别为54%（50例中27例）和41.9%（31例中13例）。非典型子宫内膜异位症见于18例透明细胞癌、7例子宫内膜样癌、4例浆液性癌、3例黏液性交界性肿瘤和1例浆液性交界性肿瘤。13例不典型子宫内膜异位症与恶性上皮病灶相邻。我们认为非典型子宫内膜异位症具有癌前病变的潜力，或者最常与透明细胞癌和子宫内膜样癌相关。卵巢子宫内膜异位症的细胞异型或增生的密切筛选和非典型子宫内膜异位症患者的仔细长期随访是必要的。
The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline rumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial rumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.