Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation
Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation
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DOI：
10.1055/s-0037-1615158
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发表时间：
1998-07-01
影响因子：
6.7
通讯作者：
Palotie, A
中科院分区：
文献类型：
--
作者：
Wartiovaara, U;Salven, P;Palotie, A
VEGF-C 是最近鉴定的一种内皮生长因子，其结构与血管内皮生长因子 (VEGF) 相关。我们研究了外周血细胞和脐带血CD 34+ 细胞（代表造血祖细胞）中VEGF-C 和VEGF 的表达。在CD34+细胞中检测到VEGF-C的表达。在外周血中，VEGF-C mRNA 仅限于血小板和 T 细胞。与 VEGF-C 的表达模式相反，在所有研究的外周血细胞组分以及 CD34+ 细胞中均检测到 VEGF mRNA。在急性白血病患者的新鲜骨髓样本中也检测到了VEGF-C mRNA，但表达没有表现出谱系特异性。 VEGF-C和VEGF多肽存在于血小板中，并且它们与P-血栓球蛋白的释放一起从活化的血小板中释放，表明VEGF-C和VEGF驻留在血小板的ci颗粒中。活化血小板释放的 VEGF-C 和 VEGF 可能在伤口愈合过程中的血管生成中发挥作用，也可能在其他病理状况中发挥作用，例如动脉粥样硬化、肿瘤生长和转移形成。
VEGF-C is a recently characterised endothelial growth factor structurally related to vascular endothelial growth factor (VEGF). We stud led the expression of VEGF-C and VEGF in the cells of peripheral blood and in the umbilical cord blood CD 34+ cells, representing haematopoietic progenitor cells. Expression of VEGF-C was detected in the CD34+ cells. In peripheral blood VEGF-C mRNA was restricted to platelets and T-cells. In contrast to the expression pattern of VEGF-C, VEGF mRNA was detected in all peripheral blood cell fractions studied, and also in CD34+ cells. VEGF-C mRNA was also detected in fresh bone marrow samples of acute leukaemia patients, but the expression did not show lineage specificity. VEGF-C and VEGF polypeptides were present in platelets and they were released from activated platelets together with the release of P-thromboglobulin, suggesting that VEGF-C and VEGF reside in the ci-granules of platelets. VEGF-C and VEGF, released from activated platelets, may have a role in angiogenesis during wound healing, and possibly also in other pathological conditions, such as atherosclerosis, tumour growth, and metastasis formation.