AGE-RELATED-CHANGES IN THE LIPID COMPOSITIONS OF RAT AND HUMAN-TISSUES
AGE-RELATED-CHANGES IN THE LIPID COMPOSITIONS OF RAT AND HUMAN-TISSUES
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DOI：
10.1007/bf02535072
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发表时间：
1989-07-01
期刊：
影响因子：
1.9
通讯作者：
DALLNER, G
中科院分区：
文献类型：
--
作者：
KALEN, A;APPELKVIST, EL;DALLNER, G
本文测定了1日龄至81日龄大鼠肺、心、脾、肝、肾、胰腺和肾上腺组织中胆固醇、泛醌、二氢二苯酚、二氢二苯醚、二氢二苯醚和总磷脂的含量，并与二三百日龄大鼠的相应器官进行了比较。在衰老过程中，人体组织中的胆固醇含量没有明显变化，但在年龄最大的动物的器官中，大鼠体内的这种脂质水平适度升高。在人的胰腺和肾上腺中，泛醌含量在一岁时最高，而在其他器官中，相应的峰值在20岁时，随后随着年龄的增长而持续下降。在大鼠身上也观察到了类似的模式，在30天龄时观察到泛醌的最高浓度。人体组织中的多元醇水平随着年龄的增长而增加，但增加的程度非常不同。在肺部，这一增长是7倍，在胰腺，是150倍。在我们的材料中，大鼠组织中的多元醇含量增加了20到30倍。相比之下，苯二酚的磷酸化衍生物的水平增加到更有限的程度，即在人体组织中增加了2到6倍，在大鼠中甚至更少。这些结果表明，人和大鼠器官中的一些脂质水平在一生中以一种特有的方式发生变化。这与磷脂相反，磷脂构成了细胞脂团的主体。
The levels of cholesterol, ubiquinone, dolichol, dolichyl-P, and total phospholipids in human lung, heart, spleen, liver, kidney, pancreas, and adrenal from individuals from one-day-old to 81 years of age were investigated and compared with the corresponding organs from 2 to 300 day-old rats. The amount of cholesterol in human tissues did not change significantly during aging, but the level of this lipid in the rat was moderately elevated in the organs of the oldest animals. In human pancreas and adrenal the ubiquinone content was highest at one year of age, whereas in other organs the corresponding peak value was at 20 years of age, and was followed by continuous decrease upon further aging. A similar pattern was observed in rats, with the highest concentration of ubiquinone being observed at 30 days of age. Dolichol levels in human tissues increase with aging, but they increase to very different extents. In the lungs this increase is seven-fold, and in the pancreas it is 150-fold. The elevation in the dolichol contents of rat tissues ranges from 20 to 30-fold in our material. In contrast, the levels of the phosphorylated derivative of dolichol increased to a more limited extent, i.e., 2 to 6-fold in human tissues and even less in the rat. These results demonstrate that the levels of a number of lipids in human and rat organs ar modified in a characteristic manner during the life-span. This is in contrast to phospholipids, which constitute the bulk of the cellular lipid mass.