Visual function and brain organization in non-decussating retinal-fugal fibre syndrome.
Visual function and brain organization in non-decussating retinal-fugal fibre syndrome.
复制标题
非交叉视网膜纤维综合征的视觉功能和大脑组织。
DOI：
10.1093/cercor/10.1.2
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Shapley,RM
中科院分区：
文献类型：
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作者：
Victor,JD;Apkarian,P;Hirsch,J;Conte,MM;Packard,M;Relkin,NR;Kim,KH;Shapley,RM
对一名患有非交叉视网膜纤维综合征的患者进行了功能性神经影像学、心理物理学和电生理学研究，这是一种先天性的视交叉状态，其中每只眼睛的视网膜投影完全映射到同侧初级视觉皮层。功能磁共振成像（fMRI）研究表明，对于单眼呈现的简单视觉刺激，只有同侧纹状皮层被激活。在每个半球的纹状皮层内，两个半场的表征广泛重叠。尽管存在这种严重的错误接线，但需要精确几何信息（例如游标敏锐度）的视觉功能是正常的，并且没有证据表明重叠的同侧和对侧表征之间存在视觉信息的混淆。对比敏感度和速度判断异常，但它们对目标方向和速度的依赖性表明，这种缺陷是由于眼睛不稳定造成的，而不是接线本身错误。在视觉搜索、视觉命名或虚幻轮廓感知方面没有观察到性能不对称。在单眼观察条件下对后两项任务的功能磁共振成像分析表明纹状体和前纹状体区域的双侧广泛激活。因此，该患者所实现的非常正常的视觉行为是视觉通路的可塑性和半球之间信息有效传递的结果。
Functional neuroimaging, psychophysical and electrophysiological investigations were performed in a patient with non-decussating retinal–fugal fibre syndrome, an inborn achiasmatic state in which the retinal projections of each eye map entirely to the ipsilateral primary visual cortex. Functional magnetic resonance imaging (fMRI) studies showed that for monocularly presented simple visual stimuli, only the ipsilateral striate cortex was activated. Within each hemisphere's striate cortex, the representation of the two hemifields overlapped extensively. Despite this gross miswiring, visual functions that require precise geometrical information (such as vernier acuity) were normal, and there was no evidence for the confounding of visual information between the overlapping ipsi-lateral and contralateral representations. Contrast sensitivity and velocity judgments were abnormal, but their dependence on the orientation and velocity of the targets suggests that this deficit was due to ocular instabilities, rather than the miswiringper se. There were no asymmetries in performance observed in visual search, visual naming or illusory contour perception. fMRI analysis of the latter two tasks under monocular viewing conditions indicated extensive bilateral activation of striate and prestriate areas. Thus, the remarkably normal visual behavior achieved by this patient is a result of both the plasticity of visual pathways, and efficient transfer of information between the hemispheres.