Intravascular lymphomatosis mimicks a cerebral demyelinating disorder.
Intravascular lymphomatosis mimicks a cerebral demyelinating disorder.
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血管内淋巴瘤病类似于脑脱髓鞘疾病。
作者：
Chooi;W. Shyu;W. Tsao;Hung Li
血管内淋巴瘤病是一种罕见的结外形式的弥漫性大 B 细胞非霍奇金淋巴瘤，可引起多种神经系统症状，包括局灶性神经功能缺损、认知能力下降和癫痫发作。由于其临床表现多变且实验室检查结果非特异性，血管内淋巴瘤病很难进行生前诊断。血管内淋巴瘤患者的神经影像学结果也存在很大差异。在此，我们介绍了一名神经功能缺损迅速恶化的患者，其脑部 MRI 显示其白质疾病正在迅速进展。该患者被诊断为患有脑脱髓鞘疾病并接受治疗。尸检后最终确诊为累及多个器官的血管内淋巴瘤。
Intravascular lymphomatosis is a rare extra-nodal form of diffuse, large B-cell non-Hodgkin's lymphoma that causes a myriad of neurological symptoms, including focal neurological deficits, cognitive decline, and seizure. Intravascular lymphomatosis is difficult to make ante-mortem diagnosis because of its variable clinical presentation and non-specific laboratory findings. Neuroimaging findings also vary widely in patients of intravascular lymphomatosis. We present, herein, a patient with rapidly deteriorating neurological deficit whose brain MRI revealed rapidly progressing white matter diseases. This patient was diagnosed and treated as having a cerebral demyelinating disorder. Intravascular lymphomatosis involving multiple organs was finally diagnosed after autopsy.