Changes in brain metabolism associated with remission in unipolar major depression
Changes in brain metabolism associated with remission in unipolar major depression
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DOI：
10.1111/j.1600-0447.2004.00351.x
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发表时间：
2004-09-01
影响因子：
6.7
通讯作者：
Herholz, K
中科院分区：
文献类型：
--
作者：
Holthoff, VA;Beuthien-Baumann, B;Herholz, K
目的：用正电子发射断层扫描（PET）和f -18-氟脱氧葡萄糖测定重度抑郁症（MDD）患者缓解的脑功能相关因素。方法：测量急性抑郁期间中度至重度重度重度抑郁症患者（n = 41）的葡萄糖代谢，缓解状态定义为无症状状态超过12周。数据分析使用了兴趣区域（ROI）方法和统计参数映射（SPM）。结果：与基线扫描相比，缓解后左前额叶、颞叶前部、前扣带皮层和双侧丘脑（SPM分析）以及双侧壳核和小脑（SPM和ROI分析）的代谢显著降低。前额叶和前扣带皮层代谢明显不对称，左半球代谢较低，尽管临床缓解，但仍持续存在。结论：这些发现支持了选择性单胺再摄取抑制导致介导抑郁症状的脑回路衰减的假设。
Objective: Functional brain correlates of remission in patients with major depressive disorder (MDD) are measured with positron emission tomography (PET) and F-18-fluorodeoxyglucose.Method: Glucose metabolism was measured in patients (n = 41) with moderate to severe MDD during acute depression and in the remitted state defined as a period of asymptomatic condition over 12 weeks. Data analyses used a region-of-interest (ROI) approach and statistical parametric mapping (SPM).Results: There were significant decreases in metabolism upon remission with respect to the baseline scan in left prefrontal, anterior temporal and anterior cingulate cortex and bilateral thalamus (SPM analysis) and bilateral putamen and cerebellum (SPM and ROI analyses). There was a significant asymmetry in prefrontal and anterior cingulate cortex metabolism with lower metabolism in the left hemisphere that persisted despite clinical remission.Conclusion: These findings support the hypothesis that selective monoamine reuptake inhibition leads to an attenuation of a brain circuit that mediates depressive symptomatology.