Lipid peroxidation products as predictors of oxidant-mediated disease in preterm infants
Lipid peroxidation products as predictors of oxidant-mediated disease in preterm infants
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DOI：
10.1080/14767058.2020.1869934
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发表时间：
2020-12-29
影响因子：
1.8
通讯作者：
Weinberger, Barry
中科院分区：
文献类型：
--
作者：
Katti, Karishma;Ayasolla, Kamesh R.;Weinberger, Barry
研究背景早产儿易患“氧自由基病”（oxygen radical diseases，ORD）。8-异前列烷（8-IP）是由活性氧催化花生四烯酸过氧化反应产生的生物活性类二十烷酸。丙二醛（MDA）是由氧化剂诱导的脂质氢过氧化物分解产生的。我们假设，发展的ORD是与血浆8-IP升高的第0-1天，并增加尿液中MDA的水平在第一个month.MethodsPreterm（=阶段1，积气，或氧需求在36周校正gestational age.ResultsPlasma 8-IP是较高的0-1天在早产儿发展的ORD相比，足月儿。早产儿尿TBARS水平在0 ~ 1 ~ 28 d升高，但在合并或不合并ORD的早产儿中无显著差异。发生ORD的早产儿尿TBARS水平在1 ~ 14 d显著升高。如果被证实为一个生物标志物的ORD，它可能是有用的指导抗氧化治疗最易感的婴儿。足月儿、合并ORD的早产儿和未合并ORD的早产儿第1个月尿TBARS无显著差异，但前2周TBARS快速升高可能与ORD相关。
BackgroundPreterm infants are susceptible to "oxygen radical diseases" (ORD). 8-isoprostane (8-IP) is a bioactive eicosanoid generated by reactive oxygen species-catalyzed peroxidation of arachidonic acid. Malondialdehyde (MDA) is generated by the decomposition of oxidant-induced lipid hydroperoxides. We hypothesize that the development of ORD is associated with elevated plasma 8-IP on day 0-1, and increasing urine levels of MDA in the first month.MethodsPreterm (= stage 1, pneumatosis, or oxygen requirement at 36 weeks corrected gestational age.ResultsPlasma 8-IP was higher on day 0-1 in preterm infants who developed ORD compared to term infants. Urine TBARS levels increased in preterm infants from day 0-1 to day 28 but were not different in infants with or without ORD. Preterm infants who developed ORD demonstrated a significant rise in urine TBARS levels from day 1 to 14.ConclusionsElevated plasma 8-IP on day 1 is associated with ORD in preterm infants. If validated as a biomarker for ORD, it may be useful in directing antioxidant therapies to the most susceptible infants. Urine TBARS during the first month are not significantly different in term infants, preterm infants with ORD, and preterm infants without ORD, but rapid rise of TBARS in the first 2 weeks may be associated with ORD.