Rheumatoid arthritis. Biosynthesis of complement proteins by synovial tissues.
Rheumatoid arthritis. Biosynthesis of complement proteins by synovial tissues.
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类风湿关节炎。
DOI：
10.1056/nejm197406062902304
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
H. Colten
中科院分区：
文献类型：
--
作者：
S. Ruddy;H. Colten
通过三种独立的技术证明了类风湿性滑膜组织合成补体成分C2、C3、C4和C5：用放射性标记的C3进行的体内代谢研究; C2、C3、C4和C5的体外生物合成;以及用C3和C4的荧光抗血清对类风湿性滑膜中的细胞进行染色。从类风湿性关节炎患者获得的组织培养物比从退行性或创伤性关节炎患者获得的组织培养物更经常观察到补体成分的产生。研究结果表明，在类风湿性关节炎的炎症反应的组成部分的本地生产的重要性。（《新英格兰医学杂志》290：1284-1288，1974）
Synthesis of complement components C2, C3, C4 and C5 by rheumatoid synovial tissue was demonstrated by three independent technics: in vivo metabolic studies with Radio-labeled C3; in vitro biosynthesis of C2, C3, C4 and C5; and staining of cells in rheumatoid synovium with fluorescent antiserums to C3 and C4. Production of complement components was more frequently observed with cultures of tissue obtained from patients with rheumatoid arthritis than with those from patients with degenerative or traumatic arthritis. The findings demonstrate the importance of local production of components of the inflammatory response in rheumatoid arthritis. (N Engl J Med 290:1284–1288, 1974)