Superiority of the Ratio Between Negative and Positive Lymph Nodes for Predicting the Prognosis for Patients With Gastric Cancer
Superiority of the Ratio Between Negative and Positive Lymph Nodes for Predicting the Prognosis for Patients With Gastric Cancer
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DOI：
10.1245/s10434-014-4121-8
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发表时间：
2015-04-01
影响因子：
3.7
通讯作者：
Liang, Han
中科院分区：
文献类型：
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作者：
Deng, Jingyu;Zhang, Rupeng;Liang, Han
为探讨淋巴结阴性与阳性比值（R-NP）对胃癌预后的预测价值，对1,563例胃癌患者的临床病理资料进行分析，探讨R-NP分期对胃癌预后的意义。在单因素生存分析中，R-NP分期和TRNPM分期均是影响胃癌患者总生存率的相关因素。与肿瘤淋巴结转移（TNM）和阳性淋巴结和清扫淋巴结（TRPDM）分类一样，TRNPM分类被确定为GC患者的独立预后预测因子，使用多变量生存分析。然而，TRNPM分类比TNM和TRPDM分类具有更小的Akaike信息标准和贝叶斯信息标准值，并且使用病例对照匹配方法证明TRNPM分类是GC患者OS的最强指标，代表了TRNPM分类在预后预测方面的相对优势。NP分期可作为临床判断胃癌预后的最佳指标。
This study aimed to elucidate the prognostic prediction superiority of the ratio between negative and positive lymph nodes (R-NP) in gastric cancer (GC).The clinicopathologic data of 1,563 GC patients were analyzed to demonstrate the prognostic significances of the R-NP stage. The tumor R-NP metastasis (TRNPM) classification system also was evaluated to determine the potential superiorities of the prognostic prediction for GC patients.In the univariate survival analysis, both R-NP stage and TRNPM classification were demonstrated to be relative factors in the overall survival (OS) of GC patients. Like the tumor-node-metastasis (TNM) and positive and dissected lymph node (TRPDM) classifications, the TRNPM classification was identified as an independently prognostic predictor of GC patients using multivariate survival analysis. However, TRNPM classification has smaller Akaike information criterion and Bayesian information criterion values than the TNM and TRPDM classifications, and TRNPM classification was demonstrated to be the most intensive indicator for the OS of GC patients using the case-control matched approach, which represented the comparative superiorities of prognostic prediction of TRNPM classification.The R-NP stage should be considered as the optimal variable for evaluating the prognosis of GC in the clinic.