One-Pot and Regiospecific Synthesis of 2,3-Disubstituted Indoles from 2-Bromoanilides via Consecutive Palladium-Catalyzed Sonogashira Coupling, Amidopalladation, and Reductive Elimination
One-Pot and Regiospecific Synthesis of 2,3-Disubstituted Indoles from 2-Bromoanilides via Consecutive Palladium-Catalyzed Sonogashira Coupling, Amidopalladation, and Reductive Elimination
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DOI：
10.1021/jo302679f
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发表时间：
2013-05-03
影响因子：
3.6
通讯作者：
Senanayake, Chris H.
中科院分区：
文献类型：
--
作者：
Lu, Bruce Z.;Wei, Han-Xun;Senanayake, Chris H.
通过连续钯催化的 Sonogashira 偶联、酰胺钯化和还原消除，开发了一种实用的一锅法和区域特异性三组分工艺，用于从 2-溴代苯胺合成 2,3-二取代吲哚。
A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium catalyzed Sonogashira coupling, amidopalladafion, and reductive elimination.