Early changes in cytokine expression in peste des petits ruminants disease.
Early changes in cytokine expression in peste des petits ruminants disease.
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DOI：
10.1186/1297-9716-45-22
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发表时间：
2014-02-22
影响因子：
4.4
通讯作者：
Baron MD
中科院分区：
文献类型：
--
作者：
Baron J;Bin-Tarif A;Herbert R;Frost L;Taylor G;Baron MD
小反刍兽疫是一种绵羊和山羊的病毒性疾病，已蔓延到非洲大部分地区以及中东和印度次大陆。虽然这种疾病的传播及其经济影响使其成为国际关注的焦点，但对这种疾病本身的性质知之甚少。我们研究了山羊感染六种不同的小反刍兽疫病毒分离株的发病早期阶段，这些分离株代表了所有四种已知的病毒谱系。没有谱系特异性差异的病毒分离株的致病性进行了观察，虽然有证据表明，即使是少量的细胞培养传代可能会影响的致病性程度的分离。在感染后4天（dpi）观察到CD4+ T细胞的一致减少。各种细胞因子表达的测量显示了经典炎症反应的要素，但也显示了白细胞介素10的相对早期诱导，这可能是导致所观察到的疾病的原因。
Peste des petits ruminants is a viral disease of sheep and goats that has spread through most of Africa as well as the Middle East and the Indian subcontinent. Although, the spread of the disease and its economic impact has made it a focus of international concern, relatively little is known about the nature of the disease itself. We have studied the early stages of pathogenesis in goats infected with six different isolates of Peste des petits ruminants virus representing all four known lineages of the virus. No lineage-specific difference in the pathogenicity of the virus isolates was observed, although there was evidence that even small numbers of cell culture passages could affect the degree of pathogenicity of an isolate. A consistent reduction in CD4+ T cells was observed at 4 days post infection (dpi). Measurement of the expression of various cytokines showed elements of a classic inflammatory response but also a relatively early induction of interleukin 10, which may be contributing to the observed disease.
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