Gamma-glutamyltransferase and diabetes - a 4 year follow-up study
Gamma-glutamyltransferase and diabetes - a 4 year follow-up study
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DOI：
10.1007/s00125-003-1036-5
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发表时间：
2003-03-01
期刊：
影响因子：
8.2
通讯作者：
Jacobs, DR
中科院分区：
文献类型：
--
作者：
Lee, DH;Ha, MH;Jacobs, DR
目标/假设。谷氨酰转移酶(GGT)位于大多数细胞的外表面，介导谷胱甘肽的摄取，谷胱甘肽是细胞内抗氧化防御的重要组成部分。GGT浓度的增加被认为是饮酒或肝脏疾病的标志。然而，GGT中更细微的梯度可能是有用的，因为它的表达被氧化应激增强，并且可以在几种诱导细胞应激的条件下释放。最近，血清GGT浓度与许多心血管疾病危险因素或胰岛素抵抗综合征的组成部分有关。我们进行了一项前瞻性研究，假设血清GGT是糖尿病事件的预测因子。1994年和1998年，共有4088名在钢铁制造公司工作的健康男性接受了检查。糖尿病的定义为空腹血糖浓度超过126 mg/dl或使用糖尿病药物。基线时血清GGT浓度与糖尿病发病率之间存在很强的剂量-反应关系。与GGT浓度低于9U/L的31%的男性相比，GGT浓度为10~19、20~29、30~39、40~49和>50U/L的男性患糖尿病的调整后相对危险度分别为8.0、13.3、12.6、19.6和25.8。基线血清GGT浓度越高，年龄和BMI与糖尿病发病的相关性越强。这项研究表明，GGT浓度在其生理范围内的增加是糖尿病发生发展的敏感和早期的生物标志物。
Aims/Hypothesis. Gamma-glutamyltransferase (GGT) is located on the external surface of most cells and mediates the uptake of gluthathione, an important component of intracellular antioxidant defenses. An increase in GGT concentration has been regarded as a marker of alcohol consumption or liver disease. However, more subtle gradations in GGT could be informative because its expression is enhanced by oxidative stress and it could be released by several conditions inducing cellular stress. Recently, serum GGT concentrations have been associated with many cardiovascular disease risk factors or components of the insulin resistance syndrome. We did a prospective study with the hypothesis that serum GGT is a predictor of incident diabetes.Methods. A total of 4,088 healthy men working in a steel manufacturing company were examined in 1994 and 1998. Diabetes was defined as a serum fasting glucose concentration of more than 126 mg/dl or the use of diabetes medication.Results. There was a strong dose-response relation between serum GGT concentrations at baseline and the incidence of diabetes. In contrast to the 31% of men with GGT concentrations under 9 U/l, adjusted relative risks for incidence of diabetes for GGT concentrations 10-19, 20-29, 30-39, 40-49, and over 50 U/l were 8.0, 13.3, 12.6, 19.6 and 25.8, respectively. The associations of age and BMI with incident diabetes became stronger the higher the value of baseline serum GGT concentration.Conclusion/interpretation. This study suggests that an increase in GGT concentration within its physiological range is a sensitive and early biomarker for the development of diabetes.