Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months
Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months
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DOI：
10.1111/desc.12015
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发表时间：
2013-03-01
影响因子：
3.7
通讯作者：
Piven, Joseph
中科院分区：
文献类型：
--
作者：
Elison, Jed T.;Wolff, Jason J.;Piven, Joseph
阐明婴儿期共同注意的神经基础有望为语言和社会认知的发展提供重要的见解，并直接为自闭症的发展模型提供信息。我们描述了一种评估婴儿对联合注意力表现的反应的新方法，该方法突出了9到10个月的时期作为最大个体差异的时间间隔。然后，我们证明，在6个月大的婴儿中测量的右钩叶束（连接杏仁核与腹内侧前额叶皮层和颞前极的白质纤维束）的部分各向异性可以预测9个月大的婴儿对联合注意的反应的个体差异。9月龄时，右驱尾肌白质微结构与接受性语言能力无关。这些发现表明，婴儿时期核心非语言社交技能的发展在很大程度上是由右侧额颞叶大脑系统的早期发展所支持的。
Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9- to 10-month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral-medial prefrontal cortex and anterior temporal pole, measured in 6-month-olds predicts individual differences in responding to joint attention at 9months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems.