Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: Results from a randomized trial
Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: Results from a randomized trial
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DOI：
10.1093/infdis/173.1.83
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发表时间：
1996-01-01
影响因子：
6.4
通讯作者：
Nelson, KE
中科院分区：
文献类型：
--
作者：
Ahmed, F;Steinhoff, MC;Nelson, KE
成人（n = 282）随机接受肺炎球菌糖蛋白结合疫苗，由与CRM相关的肺炎球菌血清型6B、14、18C、19F和23F组成（197），或23价肺炎球菌多糖疫苗。在人类免疫缺陷病毒（HIV）未感染者中，结合疫苗对血清型6B、18C和23F的IgG抗体几何平均滴度（GMTs）显著高于多糖疫苗：IgG GMTs分别为9.0比4.8、23.2比5.9和15.3比4.4 μ g/mL。相比之下，这两种疫苗在hiv感染者中引发了相似的抗体GMTs：所有血清型的GMTs范围为1.3至10.8 μ g/mL。值得注意的是，在接受多糖疫苗的人群中，CD4淋巴细胞大于或等于500/ μ L的hiv未感染者和hiv感染者的抗体GMTs相似。这些数据强调了在建议进行肺炎球菌免疫接种的所有高危人群中对新型肺炎球菌疫苗进行对照临床评估的重要性，并强调了使用现有多糖疫苗对艾滋病毒感染者进行早期免疫接种的必要性。
Adults (n = 282) were randomized to receive either a pneumococcal glycoprotein conjugate vaccine, composed of pneumococcal serotypes 6B, 14, 18C, 19F, and 23F linked to CRM(197), or a 23-valent pneumococcal polysaccharide vaccine. Among human immunodeficiency virus (HIV)-uninfected persons, conjugate vaccine elicited significantly higher IgG antibody geometric mean titers (GMTs) than did polysaccharide vaccine for serotypes 6B, 18C, and 23F: IgG GMTs were 9.0 versus 4.8, 23.2 versus 5.9, and 15.3 versus 4.4 mu g/mL, respectively. In contrast, the two vaccines elicited similar antibody GMTs in HIV-infected persons: GMTs ranged from 1.3 to 10.8 mu g/mL for all serotypes. Of note, among persons receiving polysaccharide vaccine, antibody GMTs in HIV-uninfected and -infected persons with CD4 lymphocytes greater than or equal to 500/mu L were similar. These data underscore the importance of controlled clinical evaluations of newer pneumococcal vaccines in all highrisk groups for whom pneumococcal immunization is recommended and highlight the need for early immunization of HIV-infected persons with currently available polysaccharide vaccines.