Cardiovascular and respiratory effects of cannabis in cat and rat
Cardiovascular and respiratory effects of cannabis in cat and rat
复制标题
大麻对猫和大鼠心血管和呼吸系统的影响
DOI：
10.1111/j.1476-5381.1973.tb08262.x
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发表时间：
1973
影响因子：
7.3
通讯作者：
D. Li
中科院分区：
文献类型：
--
作者：
J. Graham;D. Li
1在麻醉大鼠中，静脉注射大麻提取物（10 mg/kg）、Δ1-四氢大麻酚（THC）（0·5 mg/kg）和Δ6-THC（0·5 mg/kg）导致全身血压、脉率和呼吸频率降低。2大麻酚（lmg/kg，i. v.）也不给予大麻二酚（lmg/kg，i. v.）对大鼠的心血管和呼吸系统有任何可观察到的影响。3用阿托品（1 mg/kg，i. v.）减少Δ1-THC或提取物引起的低血压和心动过缓。4在具有自动灌注后躯的麻醉猫中，大麻提取物（10 mg/kg，i. v.）和Δ1-THC（0·2 mg/kg，静脉注射）引起低血压、心动过缓、呼吸频率降低和后肢灌注压降低。5大麻提取物和Δ1-THC均增强猫静脉注射去甲肾上腺素诱导的后肢反射性血管舒张和直接血管收缩;它们减少组胺、乙酰胆碱或双侧颈动脉闭塞引起的反射性后肢血管收缩。6.每天腹腔注射大麻提取物（50毫克/千克）14天后，大鼠对大麻提取物的这些心血管和呼吸作用产生了耐受性。
1 In anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), Δ1‐tetrahydrocannabinol (THC) (0·5 mg/kg) and Δ6‐THC (0·5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate. 2 Neither cannabinol (1 mg/kg, i.v.) nor cannabidiol (1 mg/kg, i.v.) had any observed effects on the cardiovascular and respiratory systems of the rat. 3 Pretreatment of rats with atropine (1 mg/kg, i.v.) reduced the hypotension and bradycardia caused by Δ1‐THC or the extract. 4 In anaesthetized cats with autoperfused hindquarters, cannabis extract (10 mg/kg, i.v.) and Δ1‐THC (0·2 mg/kg, i.v.) caused hypotension, bradycardia, depression of respiratory rate and reduction of hindlimb perfusion pressure. 5 Both cannabis extract and Δ1‐THC potentiated reflex vasodilatation and direct vasoconstriction in the hindlimb induced by intravenous noradrenaline in the cat; they reduced reflex hindlimb vasoconstriction elicited by histamine, acetylcholine or bilateral carotid occlusion. 6 Tolerance to these cardiovascular and respiratory effects of cannabis extract developed in rats which had been treated i.p. with the extract at (50 mg/kg) per day for 14 days.