Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala.
Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala.
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可卡因戒断通过减少杏仁核的GABA能传播减少了MGlur介导的长期增强。
DOI：
10.1111/j.1460-9568.2011.07769.x
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Schmidt K;Krishnan B;Xia Y;Sun A;Orozco-Cabal L;Pollandt S;Centeno M;Genzer K;Gallagher JP;Shinnick-Gallagher P;Liu J
Cocaine relapse can occur when cocaine-associated environmental cues induce craving. Conditioned place preference (CPP) is a behavioral paradigm modeling the association between cocaine exposure and environmental cues. The amygdala is involved in cocaine-cue associations with the basolateral amygdala (BLA) and central amygdala (CeA) acting differentially in cue-induced relapse. Activation of metabotropic glutamate receptors induces synaptic plasticity, the mechanism of which is thought to underlie learning, memory and drug-cue associations. The goal of this study was to examine the neural alterations in responses to group I mGluR agonists in the BLA to lateral capsula of CeA (BLA-CeLc) pathway in slices from rats exposed to cocaine-CPP conditioning and withdrawn for 14 days. MGluR1 but not mGluR5 agonist induced long-term potentiation (mGluR1-LTP) in the BLA-CeLc pathway was reduced in rats withdrawal from cocaine for 2 days and 14 days, and exhibited an altered concentration response to picrotoxin. Cocaine withdrawal also reduced GABAergic synaptic inhibition in CeLc neurons. Blocking cannabinoid receptor 1 (CB1) reduced mGluR1-LTP in saline-treated but not cocaine-withdrawn group. Response to CB1 but not CB2 agonist was altered after cocaine. Additionally, increasing endocannabinoid levels abolished mGluR1-LTP in saline but not cocaine-withdrawn group. However, CB1 and CB2 protein levels were increased in the amygdala of cocaine-withdrawn rats while mGluR1 and mGluR5 remained unchanged. These data suggested that the mechanisms underlying the diminished mGluR1-LTP in cocaine-withdrawn rats involve an altered GABAergic synaptic inhibition mediated by modulation of downstream endocannabinoid signaling. These changes may ultimately result in potentiated responses to environmental cues which would bias behavior toward drug-seeking.
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影响因子：
5.3
作者：
Fourgeaud, L;Mato, S;Manzoni, OJ
通讯作者：
Manzoni, OJ
影响因子：
5.3
作者：
Domenici, Maria R.;Azad, Shahnaz C.;Rammes, Gerhard
通讯作者：
Rammes, Gerhard
影响因子：
5.3
作者：
Caille, Stephanie;Alvarez-Jaimes, Lily;Parsons, Loren H.
通讯作者：
Parsons, Loren H.
影响因子：
2
作者：
Azad, SC;Eder, M;Rammes, G
通讯作者：
Rammes, G
影响因子：
82.9
作者：
De Vries, TJ;Shaham, Y;Schoffelmeer, ANM
通讯作者：
Schoffelmeer, ANM