THE EFFECTS OF 22 ORGANOCHLORINE PESTICIDES AS INDUCERS OF THE HEPATIC DRUG-METABOLIZING-ENZYMES
THE EFFECTS OF 22 ORGANOCHLORINE PESTICIDES AS INDUCERS OF THE HEPATIC DRUG-METABOLIZING-ENZYMES
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DOI：
10.1016/0306-3623(83)90028-9
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
SAFE, S
中科院分区：
文献类型：
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作者：
CAMPBELL, MA;GYORKOS, J;SAFE, S
本文研究了22种有机卤农药对未成年雄性Wistar大鼠肝脏药物代谢酶的诱导作用。该组包括4种异构体BHC、工业氯丹、γ-氯氰菊酯、氧氯菊酯、反式九氯、七氯、环氧七氯、艾氏剂、狄氏剂、酮、毒杀芬、灭蚁灵、六氯苯和若干滴滴涕类似物。除六氯苯外，所有农药均诱导微粒体二甲基氨基安替比林N-脱甲基酶和艾氏剂环氧酶的活性，与对照大鼠相比，用大多数化合物预处理的动物微粒体的细胞色素P-450含量也有所增加。这些农药的诱导方式都类似于苯巴比妥。六氯苯作为微粒体酶诱导剂的效果类似于苯巴比妥加3-甲基胆蒽共同给药后观察到的效果。
The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat were determined. This group included 4 isomeric BHC, technical chlordane, .gamma.-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all pesticides induced microsomal dimethylaminoantipyrine N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most compounds was also increased compared to control rats. These pesticides all resembled phenobarbitone in their mode of induction. The effects of HCB as a microsomal enzyme inducer resembled those observed after coadministration of phenobarbitone plus 3-methylcholanthrene.