Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.
Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.
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妊娠期间母亲血清镉水平及其与小于胎龄儿的关系：基于人群的出生队列研究
DOI：
10.1038/srep22631
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发表时间：
2016-03-03
影响因子：
4.6
通讯作者：
Xu DX
中科院分区：
文献类型：
--
作者：
Wang H;Liu L;Hu YF;Hao JH;Chen YH;Su PY;Fu L;Yu Z;Zhang GB;Wang L;Tao FB;Xu DX
妊娠期母体镉（Cd）暴露与胎儿生长受限（FGR）风险增加之间的关系仍存在争议。本研究评估了中国人群中母亲血清Cd水平与小胎龄儿（SGA）风险之间的关系。本研究分析了C-ABCS队列的一个子样本，该队列招募了3254对符合条件的母亲和独生子女对。采用石墨炉原子吸收光谱法测定孕妇妊娠期血清镉水平。计算SGA婴儿的发生率和比值比（OR）。H-Cd（≥1.06 μg/L）组SGA发生率为10.6%，显著高于L- cd （<1.06 μg/L）组的7.5%。H-Cd患者的or为1.45 （95%CI: 1.11, 1.90；P= 0.007）。在H-Cd组中，SGA婴儿的调整系数为1.43 （95%CI: 1.09, 1.88；P= 0.007）。综上所述，我们观察到，与妊娠早期相比，妊娠中期母体接触Cd会增加SGA的风险。本研究结果具有一定的研究价值，值得进一步探讨。
The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite furnace atomic absorption spectrometry. The rate and odds ratio (OR) for SGA infant were calculated. The rate for SGA infant was 10.6% among subjects with H-Cd (≥1.06 μg/L), significantly higher than 7.5% among subjects with L-Cd (<1.06 μg/L).ORwas 1.45 (95%CI: 1.11, 1.90;P= 0.007) among subjects with H-Cd. AdjustedORfor SGA infants was 1.43 (95%CI: 1.09, 1.88;P= 0.007) among subjects with H-Cd. Taken together, we observe the fact that maternal Cd exposure at middle gestational stage, elevates the risk of SGA in contrast to early gestational stage. The present results might be interesting and worth more discussing, and guarantee to further studies.