Structural studies of phospholipid cubic phases
Structural studies of phospholipid cubic phases
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磷脂立方相的结构研究
DOI：
--
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
E. Pebay‐Peyroula
中科院分区：
文献类型：
--
作者：
J. Seddon;J. Hogan;N. A. Warrender;E. Pebay‐Peyroula
在我们以前的工作中，我们已经表明，饱和磷脂酰乙醇胺的一般特征是，它们表现出层状逆六方（HII）相变随着温度的升高，在所有的水含量。我们已经发现，减少的脂质链长C12（双十二烷基）的影响是导致出现三个中间双连续立方相在不同区域的二元相图。我们已经确定这些相位为立方4，8和12，对应于可能的空间群Pn 3 m（Q224），Im 3 m（Q229）和Ia 3d（Q230）。此外，我们发现，对于C16（双十六烷基）脂质，立方相也诱导在定性的相同区域的相图的极性头基的甲基化，这增加了其亲水性。我们已经研究了脂质的手性是否会影响所形成的立方相的手性，并且已经发现，至少对于这些磷脂，它不会。我们还发现，立方相形成的水合磷脂酰胆碱/脂肪酸1/2（摩尔/摩尔）的化学计量混合物，当链长减少，我们报告这些系统的X-射线和中子衍射得到的初步结果。
In our previous work, we have shown that a general feature of saturated phosphatidylethanolamines is that they exhibit lamellar — inverse hexagonal (HII) phase transitions with increasing temperature, at all water contents. We have found that the effect of decreasing the lipid chainlength to C12(didodecyl) is to cause the appearance of three intermediate bicontinuous cubic phases in different regions of the binary phase diagram. We have identified these phases as being of cubic aspects 4, 8 and 12, corresponding to probable spacegroups Pn3m (Q224), Im3m (Q229) and Ia3d (Q230). Furthermore, we find that for the C16(dihexadecyl) lipid, cubic phases are also induced in qualitatively the same regions of the phase diagram by methylation of the polar headgroup, which increases its hydrophilicity. We have investigated whether the chirality of the lipid influences the chirality of the cubic phase formed, and have found that, at least for these phospholipids, it does not. We have also found that cubic phases are formed by hydrated phosphatidylcholine/fatty acid 1/2 (mol/mol) stoichiometric mixtures, when the chainlength is reduced, and we report preliminary results obtained by X-ray and neutron diffraction on these systems.
影响因子：
2.9
作者：
CAFFREY, M
通讯作者：
CAFFREY, M
DOI：
10.1073/pnas.85.15.5364
发表时间：
1988-08-01
影响因子：
11.1
作者：
ANDERSON, DM;GRUNER, SM;LEIBLER, S
通讯作者：
LEIBLER, S
水合二油酰磷脂酰乙醇胺膜中倒立立方相的观察。
影响因子：
2.9
作者：
Shyamsunder,E;Gruner,SM;Tate,MW;Turner,DC;So,PT;Tilcock,CP
通讯作者：
Tilcock,CP