Global Assessment of the Impact of Type 2 Diabetes on Sleep through Specific Questionnaires. A Case-Control Study
Global Assessment of the Impact of Type 2 Diabetes on Sleep through Specific Questionnaires. A Case-Control Study
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DOI：
10.1371/journal.pone.0157579
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发表时间：
2016-06-17
期刊：
影响因子：
3.7
通讯作者：
Simo, Rafael
中科院分区：
文献类型：
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作者：
Lecube, Albert;Sanchez, Enric;Simo, Rafael
2型糖尿病（T2 D）是睡眠呼吸障碍的独立危险因素。然而，它是未知的T2 D是否影响每日嗜睡和睡眠质量独立的损害polysomnographicparameters.Material和MethodsA病例对照研究，包括413例T2 D患者和413名非糖尿病受试者，匹配的年龄，性别，BMI，腰围和颈围。进行多导睡眠描记术，并使用埃普沃思嗜睡量表（ESS）评估白天嗜睡情况。此外，135例T2 D患者和45例对照组匹配相同的先前参数也进行了评估，通过匹兹堡睡眠质量指数（PSQI）计算睡眠quality.ResultsDaytime嗜睡T2 D高于对照组（p = 0.003），与23.9%的受试者提出了过度的白天嗜睡（ESS>10）。空腹血糖（FPG >= 13.1 mmol/l）的患者被确定为ESS>10的高风险组（OR 3.9，95%CI 1.8-7.9，p = 0.0003）。逐步回归分析显示，T2 D的存在、基线血糖水平和性别，而不是多导睡眠图参数（即呼吸暂停-呼吸暂停指数或氧饱和度低于90%的睡眠时间）独立预测ESS评分。此外，T2 D受试者显示出更高的睡眠障碍[PSQI：7.0（1.0-18.0）vs. 4（0.0-12.0），p
Type 2 diabetes (T2D) is an independent risk factor for sleep breathing disorders. However, it is unknown whether T2D affects daily somnolence and quality of sleep independently of the impairment of polysomnographic parameters.Material and MethodsA case-control study including 413 patients with T2D and 413 non-diabetic subjects, matched by age, gender, BMI, and waist and neck circumferences. A polysomnography was performed and daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS). In addition, 135 subjects with T2D and 45 controls matched by the same previous parameters were also evaluated through the Pittsburgh Sleep Quality Index (PSQI) to calculate sleep quality.ResultsDaytime sleepiness was higher in T2D than in control subjects (p = 0.003), with 23.9% of subjects presenting an excessive daytime sleepiness (ESS>10). Patients with fasting plasma glucose (FPG >= 13.1 mmol/l) were identified as the group with a higher risk associated with an ESS>10 (OR 3.9, 95% CI 1.8-7.9, p = 0.0003). A stepwise regression analyses showed that the presence of T2D, baseline glucose levels and gender but not polysomnographic parameters (i.e apnea-hyoapnea index or sleeping time spent with oxigen saturation lower than 90%) independently predicted the ESS score. In addition, subjects with T2D showed higher sleep disturbances [PSQI: 7.0 (1.0-18.0) vs. 4 (0.0-12.0), p