ENHANCED SUSCEPTIBILITY TO SALMONELLA INFECTION IN STREPTOMYCIN-TREATED MICE
ENHANCED SUSCEPTIBILITY TO SALMONELLA INFECTION IN STREPTOMYCIN-TREATED MICE
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DOI：
10.1093/infdis/111.2.117
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发表时间：
1962-01-01
影响因子：
6.4
通讯作者：
MILLER, CP
中科院分区：
文献类型：
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作者：
BOHNHOFF, M;MILLER, CP
口服30-50 mg链霉素可增加小鼠对经口接种的沙门氏菌链霉素耐药菌株感染的敏感性。不到10种微生物感染了一半的治疗小鼠，但需要约106种微生物感染一半的未治疗对照。较小剂量的链霉素效果较差。链霉素的作用随治疗后时间的推移而减弱，但在第五天仍可检测到。在暴露于正常小鼠粪便微生物菌群污染的小鼠中，其损失更快。在未处理的小鼠中，小接种物通过胃肠道而不繁殖，并在24小时内排泄。在链霉素处理的小鼠中，接种物在大肠中迅速繁殖。经腹膜内或静脉途径感染不受口服链霉素的影响。口服链霉素也增加了肠道感染的易感性。口服足够剂量的青霉素可增加对沙门氏菌的敏感性。几乎和链霉素一样多。肠道易感性的增强完全归因于肠腔内链霉素（或青霉素）的抗菌作用导致的肠道微生物群落生态学的变化。
Administration per os of 30-50 mg streptomycin increased susceptibility of mice to infection with a streptomycin-resistant strain of Salmonella enteritidis inoculated per os. Fewer than 10 microorganisms infected half the treated mice, but approximately 106 were required to infect half the untreated controls. Smaller doses of streptomycin were less effective. The effect of streptomycin which diminished with time after treatment was still detectable on the fifth day. It was lost more rapidly in mice exposed to contamination with fecal microflora of a normal mouse. In untreated mice, small inocula passed through the gastrointestinal tract without multiplying and were excreted within 24 hrs. In streptomycin treated mice inocula multiplied rapidly in the large intestine. Infection by the intraperitoneal or intravenous route was unaffected by streptomycin per os. Streptomycin per os also increased susceptibility to enteric infection with staphylococcus. Penicillin per os in sufficient dosage increased susceptibility to S. enteritidis almost as much as streptomycin. Enhanced susceptibility of the intestinal tract is ascribed solely to the change in ecology of the enteric microflora resulting from the antimicrobial action of streptomycin (or penicillin) within the lumen of the gut.