WIDESPREAD DISTRIBUTION OF NUCLEAR ANDROGEN RECEPTORS IN THE BASAL-CELL LAYER OF THE NORMAL AND HYPERPLASTIC HUMAN PROSTATE
WIDESPREAD DISTRIBUTION OF NUCLEAR ANDROGEN RECEPTORS IN THE BASAL-CELL LAYER OF THE NORMAL AND HYPERPLASTIC HUMAN PROSTATE
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DOI：
10.1007/bf01605130
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发表时间：
1993-01-01
期刊：
影响因子：
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通讯作者：
REMBERGER, K
中科院分区：
文献类型：
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作者：
BONKHOFF, H;REMBERGER, K
基本细胞层在器官发生、上皮更新和良性前列腺疾病的发展中的作用在很大程度上是未知的。本研究的目的是调查基底细胞是否表达核雄激素受体(AR)。计算机辅助图像分析免疫组织化学双重染色定位AR和基底细胞特异性细胞角蛋白在相同的切片。结果表明，在正常和增生期，基底细胞广泛表达核AR。与分泌腔细胞的染色强度相比，该受体在基底细胞中的表达水平最低，可能在局部表现出较强的AR免疫反应活性。AR高表达的基底细胞多见于增生性病变，包括萎缩后和不典型增生。基底细胞中雄激素和雌激素或孕激素的核受体的存在可能表明这些细胞是激素失衡的靶点，而激素失衡往往与良性前列腺增生症的病因有关。
The role of the basal cell layer in organogenesis, epithelial renewal and development of benign prostatic disorders is largely unknown. The objective of the present study was to investigate whether or not basal cells express the nuclear androgen receptor (AR). Computer-assisted image analyses of immunohistochemical double stainings were performed to localize AR and basal-cell-specific cytokeratins in identical sections. The results showed that the basal cells express nuclear AR widely in normal and hyperplastic conditions. When compared with the staining intensities detected in secretory luminal cells, the receptor was most frequently expressed at lower levels in basal cells, which may exhibit strong AR immunoreactivity focally. Basal cells with increased AR expression were most frequently detected in hyperplastic lesions including post-atrophic and atypical hyperplasia. The presence of nuclear receptors for both androgens and oestrogens or progestins in basal cells may indicate that these cells are targets of the hormonal imbalance which has frequently been implicated in the aetiology of benign prostatic hyperplasia.