Chromosome segregation machinery and cancer
Chromosome segregation machinery and cancer
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DOI：
10.1111/j.1349-7006.2009.01178.x
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发表时间：
2009-07
期刊：
影响因子：
5.7
通讯作者：
Kozo Tanaka;T. Hirota
中科院分区：
文献类型：
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作者：
Kozo Tanaka;T. Hirota
染色体的丢失或获得与许多癌细胞有关。这种特性称为染色体不稳定性，可能是由于染色体分离机制的损伤引起的。染色体分离的关键是微管与动粒的正确连接，以及后期姐妹染色单体的同步分离。这些过程的准确性是由两个复杂的机器，称为校正机制和主轴组装检查点。在这里，我们概述了目前对潜在机制的理解，并强调了最近的挑战性实验，以解决染色体分离失败可能与肿瘤发生。了解这些机制可能会导致发现新的和改进的抗癌疗法。（Cancer Sci 2009; 100：1158-1165）
Loss or gain of chromosomes is associated with many cancer cells. This property, called chromosome instability, might arise from a lesion in the chromosome segregation machinery. Essential for chromosome segregation are the proper connection of microtubules to kinetochores, and the synchronous segregation of sister chromatids in anaphase. Accuracy of these processes is ensured by two sophisticated machineries called the correction mechanism and the spindle assembly checkpoint. Here we outline the current understanding of the underlying mechanisms, and highlight recent challenging experiments to address how chromosome segregation failure might relate to tumorigenesis. Understanding these mechanisms may lead to the discovery of new and improved anticancer therapies. (Cancer Sci 2009; 100: 1158–1165)