Disseminated superficial actinic porokeratosis (DSAP).
Disseminated superficial actinic porokeratosis (DSAP).
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DOI：
10.1001/archderm.1967.01610060005001
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发表时间：
1967-12
影响因子：
--
通讯作者：
M. E. Chernosky;Robert G. Freeman
中科院分区：
文献类型：
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作者：
M. E. Chernosky;Robert G. Freeman
本研究对31例患者进行了研究，发现弥散性浅表面性光化性角化症（DSAP）是一种独特的、可识别的实体，其特征是在生命的第三或第四个十年中，在皮肤暴露于阳光下的区域发生许多均匀的小的、极小的、环状的、无汗性的角化病变。这种情况并不罕见。虽然DSAP的许多临床特征不同于典型的多孔角化症（Mibelli），但其组织学特征基本相同，包括典型的角膜片状，但特征通常很小。在6次自体移植病变部分的尝试中，3次成功。自然或实验紫外光照射后的恶化，病变局限于皮肤暴露区域的分布，以及与真正的光化性角化病频繁的临床和组织学相似性表明，光化性角化病在DSAP的发病机制中起重要作用。
This study of 31 patients presents disseminated superficial actinic porokeratosis (DSAP) as a distinctive and recognizable entity characterized by many uniformly small, minimal, annular, anhidrotic, keratotic lesions developing during the third or fourth decade of life on sun-exposed areas of skin. It is not a rare condition. While many clinical features of DSAP differ from the classic type of porokeratosis (Mibelli), the histologic features are essentially the same including the typical cornoid lamella, but the features are often minimal. Of six attempts to autotransplant portions of lesions, three were successful. Exacerbation following natural or experimental ultraviolet light radiation, distribution of lesions limited to sun-exposed areas of skin, and frequent clinical and histologic similarities to true actinic keratoses indicate that actinic radiation plays an important role in the pathogenesis of DSAP.