ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA-COLI UNDERGOING INDUCED BETA-GALACTOSIDASE SYNTHESIS
ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA-COLI UNDERGOING INDUCED BETA-GALACTOSIDASE SYNTHESIS
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DOI：
10.1128/jb.78.5.613-623.1959
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发表时间：
1959-01-01
影响因子：
3.2
通讯作者：
HORIBATA, K
中科院分区：
文献类型：
--
作者：
COHN, M;HORIBATA, K
当诱导下系统的代谢活性对于该系统的形成至关重要时，群体中每个细胞的反应严重依赖于它是否拥有最小单位的诱导活性。因此，群体形成酶是异质的。酶的形成和不形成都通过克隆传递给后代。两个诱导系统：E.大肠杆菌的半乳糖酶和长期适应酵母的半乳糖酶（Spiegelman，1951）可以根据这一概念来理解，对此提出了实验证据。
When the metabolic Activity of a system under induction is essential to the formation of that system, the response of each cell in a population is sharply dependent upon whether it possesses a minimum unit of the induced activity. As a result, the formation of enzyme by the population is heterogenous. Both the formation and nonformation of enzyme is passed on clonally to the descendants. Two induced systems: the galactoside-permease and [beta]-galactosidase (Cohen and Monod, 1957) of E. coli and the galactozymase of long-term adapting yeast (Spiegelman, 1951) can be understood in terms of this concept for which experimental evidence is presented.