Antibacterial Activity Against Escherichia coli of Cu-BTC (MOF-199) Metal-Organic Framework Immobilized onto Cellulosic Fibers
Antibacterial Activity Against Escherichia coli of Cu-BTC (MOF-199) Metal-Organic Framework Immobilized onto Cellulosic Fibers
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DOI：
10.1002/app.40815
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发表时间：
2014-10-05
影响因子：
3
通讯作者：
Soto, Carlos Y.
中科院分区：
文献类型：
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作者：
Rodriguez, Haendel S.;Hinestroza, Juan P.;Soto, Carlos Y.
据报道，固定在纤维素纤维上的 Cu-BTC 金属有机骨架对大肠杆菌具有很强的抗菌活性。 Cu-BTC 金属有机框架（又名 MOF-199 或 HKUST-1）在纤维素基材上的原位合成是通过将羧甲基化纤维素基材按照非常特定的顺序暴露于 Cu(OAC)(2)、1,3,5-苯三甲酸和三乙胺溶液中来进行的。根据 ASTM E2149-13a 使用体外模型，我们观察到纤维素-MOF 系统能够完全消除琼脂平板和液体培养物上大肠杆菌的生长。还评估了MOF-199的组成成分和纤维素底物的抗菌活性，并确定其可以忽略不计。由于用于合成 MOF-199 晶体的方法在晶体和纤维素基材之间提供了牢固的结合，因此晶体不会与阴离子纤维素纤维分离，从而使改性纺织品可以清洗和重复使用，从而为制造抗菌临床织物开辟了新途径。 (C) 2014 年 Wiley 期刊公司。
A strong antimicrobial activity against Escherichia coli of Cu-BTC metal-organic frameworks immobilized over cellulosic fibers is hereby reported. The in situ synthesis of Cu-BTC metal-organic frameworks, aka MOF-199 or HKUST-1, onto cellulosic substrates was carried out by exposing carboxymethylated cellulosic substrates to Cu(OAC)(2), 1,3,5-benzenetricarboxylic acid and triethylamine solutions following a very specific order. Using an in vitro model, in accordance to ASTM E2149-13a, we observed that the cellulose-MOF system was able to completely eliminate the growth of E. coli on agar plates and liquid cultures. The antibacterial activity of the comprising components of MOF-199 and the cellulosic substrate was also evaluated and determined to be negligible. Since the method used to synthesize MOF-199 crystals provides a strong bond between the crystals and the cellulosic substrates, the crystals not detach from the anionic cellulosic fibers allowing the modified textile to be washed and reused hence opening a new avenue to fabricate antibacterial clinical fabrics. (C) 2014 Wiley Periodicals, Inc.