Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies
Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies
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DOI：
10.1016/j.jsbmb.2004.12.006
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发表时间：
2005-02-01
影响因子：
4.1
通讯作者：
Gee, JMW
中科院分区：
文献类型：
--
作者：
Nicholson, RI;Hutcheson, IR;Gee, JMW
最近的证据表明，生长因子网络在控制乳腺癌生长和发展方面与雌激素受体（ER）高度相互作用。因此，肿瘤对抗激素的反应可能是这些药物的 ER 和生长因子抑制活性的复合体，生长因子信号传导的改变/畸变提供了抗激素耐药性发展的机制。有鉴于此，本文重点阐述了我们内部乳腺癌肿瘤模型中生长因子信号传导与抗激素失败之间的关系，并描述了我们现在如何开始成功地瞄准它们的作用，以改善抗激素药物的效果并阻止侵袭性疾病的进展。 (c) 2004 年，爱思唯尔有限公司出版。
Recent evidence demonstrates that growth factor networks are highly interactive with the estrogen receptor (ER) in the control of breast cancer growth and development. As such, tumor responses to anti-hormones are likely to be a composite of the ER and growth factor inhibitory activity of these agents, with alterations/aberrations in growth factor signalling providing a mechanism for the development of anti-hormone resistance. In this light, the current article focuses on illustrating the relationship between growth factor signalling and anti-hormone failure in our in-house tumor models of breast cancer and describes how we are now beginning to successfully target their actions to improve the effects of anti-hormonal drugs and to block aggressive disease progression. (c) 2004 Published by Elsevier Ltd.