Imaging inflammation in acute brain ischemia
Imaging inflammation in acute brain ischemia
复制标题
DOI：
10.1161/01.str.0000250048.42916.ad
复制
发表时间：
2007-02-01
期刊：
影响因子：
8.3
通讯作者：
Saleh, Andreas
中科院分区：
文献类型：
--
作者：
Jander, Sebastian;Schroeter, Michael;Saleh, Andreas
脑部炎症有望成为缺血性中风亚急性阶段的治疗靶点。在细胞水平上，缺血后炎症由先天免疫系统的细胞主导，其中驻留的小胶质细胞/脑巨噬细胞和血液来源的单核细胞/巨噬细胞是最重要的涉及细胞类型。氧化铁纳米粒子，例如超小超顺磁性氧化铁 (USPIO) 是用于 MRI 的新型细胞特异性造影剂。静脉注射后，USPIO 被循环吞噬细胞吸收。负载 USPIO 的巨噬细胞会引起梗塞脑实质 MRI 中的典型信号变化，这一点已在实验性缺血和人类中风的研究中得到证实。因此，USPIO 增强 MRI 可能是解决基础科学和临床研究中巨噬细胞在缺血性病变发展中的作用的重要工具。 （中风。2007；38[第 2 部分]：642-645。）
Brain inflammation holds promise as a therapeutic target in subacute stages of ischemic stroke. At the cellular level, postischemic inflammation is dominated by cells of the innate immune system with resident microglia/brain macrophages and blood-derived monocytes/macrophages being the most important cell types involved. Iron oxide nanoparticles such as ultrasmall superparamagnetic iron oxide (USPIO) are novel cell-specific contrast agents for MRI. After intravenous injection USPIO is taken up by circulating phagocytic cells. USPIO-laden macrophages cause typical signal changes in MRI of infarcted brain parenchyma, which has been demonstrated in studies of both experimental ischemia and human stroke. USPIO-enhanced MRI may therefore represent an important tool to address the role of macrophages for ischemic lesion development both in basic science and clinical studies. (Stroke. 2007;38[part 2]: 642-645.)