Effects of uncertainty in head tissue conductivity and complexity on EEG forward modeling in neonates
Effects of uncertainty in head tissue conductivity and complexity on EEG forward modeling in neonates
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DOI：
10.1002/hbm.23263
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发表时间：
2016-10-01
影响因子：
4.8
通讯作者：
Wallois, Fabrice
中科院分区：
文献类型：
--
作者：
Azizollahi, Hamed;Aarabi, Ardalan;Wallois, Fabrice
在这项研究中，我们调查了头部组织电导率的不确定性和固有的几何复杂性，包括在新生儿的<$N的影响。基于MR和CT图像配准，我们创建了一个逼真的新生儿头部模型，包括头皮，颅骨，<$颅，脑脊液（CSF），灰质（GM），白色（WM）。利用计算机模拟，我们研究了排除CSF和<$anels，GM和WM之间的歧视，和不确定性的新生儿头部组织的电导率EEG正演建模的影响。我们发现，从头部模型中排除CSF引起的EEG前向解的最强的广泛影响。GM和白色物质之间的歧视也引起了强烈的广泛影响，但强度低于CSF排除。结果还表明，从新生儿头部模型中排除的<$anels局部影响的区域，但这种影响是不明显的，比排除CSF和GM/WM的歧视。GM/WM电导率相对于参考值的25%的变化引起相当大的影响，在EEG正向解决方案，但这种影响是更明显的GM电导率。类似地，颅骨电导率的变化在颅骨覆盖的区域中的EEG正演建模中引起影响。对EEG的影响最小的是由<$门的电导率变化引起的。我们的研究结果清楚地强调了在新生儿脑电活动的建模研究和本地化的不确定性的影响，在头部组织隔室的电导率和缺陷。《脑地图》37：3604-3622，2016。(c)2016 Wiley Periodicals，Inc.
In this study, we investigated the impact of uncertainty in head tissue conductivities and inherent geometrical complexities including fontanels in neonates. Based on MR and CT coregistered images, we created a realistic neonatal head model consisting of scalp, skull, fontanels, cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM). Using computer simulations, we investigated the effects of exclusion of CSF and fontanels, discrimination between GM and WM, and uncertainty in conductivity of neonatal head tissues on EEG forward modeling. We found that exclusion of CSF from the head model induced the strongest widespread effect on the EEG forward solution. Discrimination between GM and white matter also induced a strong widespread effect, but which was less intense than that of CSF exclusion. The results also showed that exclusion of the fontanels from the neonatal head model locally affected areas beneath the fontanels, but this effect was much less pronounced than those of exclusion of CSF and GM/WM discrimination. Changes in GM/WM conductivities by 25% with respect to reference values induced considerable effects in EEG forward solution, but this effect was more pronounced for GM conductivity. Similarly, changes in skull conductivity induced effects in the EEG forward modeling in areas covered by the cranial bones. The least intense effect on EEG was caused by changes in conductivity of the fontanels. Our findings clearly emphasize the impact of uncertainty in conductivity and deficiencies in head tissue compartments on modeling research and localization of brain electrical activity in neonates. Hum Brain Mapp 37:3604-3622, 2016. (c) 2016 Wiley Periodicals, Inc.