Glucocorticoids in the control of neuroinflammation
Glucocorticoids in the control of neuroinflammation
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DOI：
10.1016/j.mce.2007.03.007
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发表时间：
2007-09
影响因子：
4.1
通讯作者：
D. Tischner;H. Reichardt
中科院分区：
文献类型：
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作者：
D. Tischner;H. Reichardt
糖皮质激素是一类类固醇激素，具有很强的抗炎和免疫抑制作用。内源性糖皮质激素是调节免疫系统的关键角色，也是许多炎症性疾病的内分泌基础。此外，合成糖皮质激素是世界上治疗自身免疫性疾病最常用的处方药之一。本文综述了糖皮质激素对多发性硬化症（MS）及其动物模型实验性自身免疫性脑脊髓炎（EAE）的作用机制的研究进展。尽管近年来出现了新的方法，但我们对糖皮质激素控制神经炎症的机制还远远没有全面了解。
Glucocorticoids are a class of steroid hormones that are endowed with profound anti-inflammatory and immunosuppressive activities. Endogenous glucocorticoids are key players in the modulation of the immune system and establish an endocrine basis of many inflammatory diseases. In addition, synthetic glucocorticoids are amongst the most commonly prescribed drugs worldwide for the treatment of autoimmune disorders. In this review we summarize our present knowledge on the mechanisms by which glucocorticoids impact on multiple sclerosis (MS), a highly prevalent neuroinflammatory disease, and its animal model experimental autoimmune encephalomyelitis (EAE). In spite of the new methodologies that have become available during recent years, we are still far from a comprehensive picture of the mechanism by which glucocorticoids control neuroinflammation.