Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023.
Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023.
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来自球形红假单胞菌 ATCC 17023 的无毒脂质 A 的结构研究。
DOI：
10.1111/j.1432-1033.1983.tb07726.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
H. Mayer
中科院分区：
文献类型：
--
作者：
P. Salimath;J. Weckesser;W. Strittmatter;H. Mayer
本文研究了从球形红球藻ATCC 17023中分离的脂质A。一系列分析表明，β-D-葡糖胺基-1，6-D-葡糖胺作为在还原性葡糖胺的C-1和非还原性葡糖胺的C-4处携带磷酸基团的糖骨架。3-（7-十四烯酰基）氧基十四烷酸和3-氧代十四烷酸都与NH 2基团连接。3-羟基癸酸的两个残基与还原和非还原葡糖胺的C-3处的羟基连接，并且3-羟基癸酸的羟基是游离的。在游离脂质A中，还原性葡糖胺的C-4和非还原性葡糖胺的C-6处的羟基是未取代的。后者可能来自3-脱氧-D-甘露-辛酮糖酸键。本文还讨论了R. sphaeroides，这是无毒的，和脂质A型，如沙门氏菌，这是有毒的，进行了讨论。
The lipid A isolated from Rhodopseudomonas sphaeroides ATCC 17023 has been investigated. A sequence of analyses indicated beta-D-glucosaminyl-1,6-D-glucosamine as the sugar backbone carrying phosphate groups at C-1 of the reducing glucosamine and C-4 of the non-reducing glucosamine. Both 3-(7-tetradecenoyl)oxytetradecanoic and 3-oxotetradecanoic acid are linked to the NH2 groups. Two residues of 3-hydroxydecanoic acid are linked to hydroxy groups at C-3 of both reducing and non-reducing glucosamine, and the hydroxy group of 3-hydroxydecanoic acid is free. In free lipid A, the hydroxy group at C-4 of the reducing glucosamine and at C-6 of the non-reducing glucosamine are unsubstituted. The latter probably arises from a 3-deoxy-D-manno-octulosonate linkage. The structural similarities and dissimilarities existing between lipid A of R. sphaeroides, which is non-toxic, and lipid A types such as those from Salmonella, which are toxic, are discussed.
通过碳 13 核磁共振表征大肠杆菌无庚糖突变体的脂多糖。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Strain,SM;Fesik,SW;Armitage,IM
通讯作者：
Armitage,IM