Novel Molecular Signaling Method and System for Molecular Communication in Human Body
Novel Molecular Signaling Method and System for Molecular Communication in Human Body
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DOI：
10.1109/access.2020.3005603
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发表时间：
2020-03
期刊：
影响因子：
3.9
通讯作者：
A. Al-Helali;B. Liang;N. Nasser
中科院分区：
文献类型：
--
作者：
A. Al-Helali;B. Liang;N. Nasser
最近，分子通信（MC）已被认为是纳米网络的使能技术，MC被设想为使纳米机器人能够在人体中完成复杂的任务，以实现有前途的医疗应用。文献中已经提出了许多可以应用于人体的MC方法并建立了模型。本文提出了一种新的体内分子通讯方法和系统，分别称为MoSiMe和MoCoBo。该方法利用人体吸收、分布、代谢和排泄（ADME）过程对药物的影响，在药理学中称为药代动力学（PK），使人体任何一点之间的MC能够实现，而不管它们之间的距离，即使它们位于身体的不同部位并被组织和液体分开。描述了MoCoBo系统的体系结构、设计和组成以及MoSiMe方法，并介绍了不同的发射机设计，包括电信领域首次采用的新型无源发射机设计。导出了人体通道的分析模型，并根据现有的人体和动物试验进行了验证。该模型捕获了影响给药物质动力学的ADME身体过程。此外，一个实验性的MoCoBo概念验证平台，能够在发射器和接收器之间发送和接收比特流，建立并通过临床试验，动物试验和分析模型进行验证。该平台还可用于测试新型MoCoBo发射机和接收机的调制技术和设计。
Recently, Molecular Communication (MC) has been recognized as an enabling technology for nanonetworks where MC is envisioned to enable nanorobots to achieve sophisticated and complex tasks in the human body for promising medical applications. Many MC methods that can be applied in the human body have been proposed and modeled in the literature. In this paper, we propose a new method and system for Molecular Communication in the Body, denoted MoSiMe and MoCoBo, respectively. The method takes advantage of how the absorption, distribution, metabolization, and excretion (ADME) bodily processes affects drugs, referred to as Pharmacokinetics (PK) in pharmacology, to enable MC between any points of the human body regardless of their distance even if they are in different parts of the body and separated by tissues and fluids. The architecture, design and components of the MoCoBo system and MoSiMe method are described and different transmitter designs, including a novel passive transmitter design for the first time in telecommunications, are introduced. An analytical model for the body channel is derived and validated with respect to existing human and animal tests. The model captures the ADME bodily processes that affect the kinetics of substances administered to the body. Additionally, an experimental MoCoBo proof of concept platform, capable of sending and receiving a stream of bits between a transmitter and a receiver, is built and validated against clinical trials, animal tests and analytical models. The introduced platform can also be utilized to test modulation techniques and designs for new MoCoBo transmitters and receivers.