Is the risk of developing Alzheimer's disease greater for women than for men?
Is the risk of developing Alzheimer's disease greater for women than for men?
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DOI：
10.1093/aje/153.2.132
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发表时间：
2001-01-15
影响因子：
5
通讯作者：
Evans, DA
中科院分区：
文献类型：
--
作者：
Hebert, LE;Scherr, PA;Evans, DA
阿尔茨海默病（AD）患者中有很大一部分是女性;然而，目前尚不清楚这是由于疾病风险较高，还是仅仅由于AD常见的年龄段有大量女性活着。从1982年开始，对马萨诸塞州东波士顿年龄大于或等于65岁的人群的两个分层随机样本进行了详细的、结构化的临床评价，以评估流行（467人）和偶发（642人来自先前确定为无疾病的队列）可能的AD。对流行率样本的死亡率进行了长达11年的跟踪调查（至1992年12月）。年龄特异性AD发病率在性别之间无显著差异（男性vs女性，比值比= 0.92; 95%置信区间（CI）：0.51，1.67）。控制年龄，患病率也没有显着差异性别（男性与女性，比值比= 1.29; 95% CI：0.67，2.48）。AD导致的死亡风险增加不因性别而异。AD女性患者与非AD女性患者的比值比为2.07（95% CI：1.21，3.56）。男性的比值比为2.22（95% CI：1.02，4.81）。这些研究结果表明，AD女性患者数量过多是由于女性的预期寿命较长，而不是该疾病的性别特异性风险因素。
A large proportion of people with Alzheimer's disease (AD) are women; however, it is not clear whether this is due to higher risk of disease or solely to the larger number of women alive at ages when AD is common. Beginning in 1982, two stratified random samples of people aged greater than or equal to 65 years in East Boston, Massachusetts underwent detailed, structured clinical evaluation for prevalent (467 people) and incident (642 people from a cohort previously ascertained to be disease-free) probable AD. The prevalence sample was followed for mortality for up to 11 years (through December 1992). The age-specific incidence of AD did not differ significantly by sex (for men vs, women, odds ratio = 0.92; 95% confidence interval (CI): 0.51, 1.67). Controlled for age, prevalence also did not differ significantly by sex (for men vs, women, odds ratio = 1.29; 95% CI: 0.67, 2.48). The increase in risk of mortality due to AD did not vary by sex. The odds ratio for women with AD compared with women without AD was 2.07 (95% CI: 1.21, 3.56). For men, the odds ratio was 2.22 (95% CI: 1.02, 4.81). These findings suggest that the excess number of women with AD is due to the longer life expectancy of women rather than sex-specific risk factors for the disease.