Temporal dynamics of ipsilateral and contealateral motor activity during voluntary finger movement
Temporal dynamics of ipsilateral and contealateral motor activity during voluntary finger movement
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DOI：
10.1002/hbm.20038
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发表时间：
2004-09-01
影响因子：
4.8
通讯作者：
Lee, RR
中科院分区：
文献类型：
--
作者：
Huang, MX;Harrington, DL;Lee, RR
同侧运动活动的作用仍然是一个有争议的问题，部分原因是不同的研究在观察到这一活动时对其定位的差异，以及对其时间进程的不确定性。本研究使用脑磁图(MEG)来研究单侧手指运动准备过程中对侧和同侧运动活动的空间定位和时间动力学。在脑磁图记录过程中，8名右撇子正常受试者用他们的优势或非优势手进行了自定节奏的手指抬起动作。采用多开始时空多极子方法分析运动准备阶段和执行早期(-800毫秒至+30毫秒)的脑磁图反应。运动的力量。三个来源被一致定位，包括在对侧主运动区(M1)和辅助运动区(SMA)的一个来源。与运动同侧的第三个来源位于M1的前方、下方和外侧，位于运动前区(PMA)(Brodmann区[BA]6)。SMA源和同侧PMA源的峰潜伏期分别比对侧M1源的峰潜伏期早60毫秒和52毫秒。SMA源和同侧PMA源的峰值偶极强度都明显弱于对侧M1源，但彼此之间没有差异。总之，结果表明，同侧运动活动与运动前功能有关，而不是M1的活动。SMA和同侧PMA的激活过程与它们在计划运动中所扮演的角色是一致的。(C)2004年Wiley-Liss公司
The role of motor activity ipsilateral to movement remains a matter of debate, due in part to discrepancies among studies in the localization of this activity, when observed, and uncertainty about its time course. The present study used magnetoencephalography (MEG) to investigate the spatial localization and temporal dynamics of contralateral and ipsilateral motor activity during the preparation of unilateral finger movements. Eight right-handed normal subjects carried out self-paced finger-lifting movements with either their dominant or nondominant hand during MEG recordings. The Multi-Start Spatial Temporal multi-dipole method was used to analyze MEG responses recorded during the movement preparation and early execution stage (-800 msec to +30 msec). of movement. Three sources were localized consistently, including a source in the contralateral primary motor area (M1) and in the supplementary motor area (SMA). A third source ipsilateral to movement was located significantly anterior, inferior, and lateral to M1, in the premotor area (PMA) (Brodmann area [BA] 6). Peak latency of the SMA and the ipsilateral PMA sources significantly preceded the peak latency of the contralateral M1 source by 60 msec and 52 msec, respectively. Peak dipole strengths of both the SMA and ipsilateral PMA sources were significantly weaker than was the contralateral M1 source, but did not differ from each other. Altogether, the results indicated that the ipsilateral motor activity was associated with premotor function, rather than activity in M1. The time courses of activation in SMA and ipsilateral PMA were consistent with their purported roles in planning movements. (C) 2004 Wiley-Liss, Inc.