The dorsomedial hypothalamic nucleus is critical for the expression of food- entrainable circadian rhythms
The dorsomedial hypothalamic nucleus is critical for the expression of food- entrainable circadian rhythms
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DOI：
10.1038/nn1651
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发表时间：
2006-03-01
影响因子：
25
通讯作者：
Saper, CB
中科院分区：
文献类型：
--
作者：
Gooley, JJ;Schomer, A;Saper, CB
行为和生理的昼夜节律可以被限制食物供应的每日周期所夹带，但介导食物夹带的途径尚不清楚。下丘脑背内侧核（DMH）对于昼夜节律的表达至关重要，并接收来自监测食物供应的系统的输入。在这里，我们报告说，限制喂养同步的每日节奏的DMH活动在大鼠中，c-Fos表达的DMH是最高的在预定的用餐时间。在食物限制期间，未受损大鼠的运动活动，体温和觉醒表现出显着的餐前上升，这些反应被DMH中的细胞特异性病变所阻断。此外，食物夹带的程度与剩余的DMH神经元的数量，和周围的DMH细胞群的病变并没有阻止夹带食物。这些结果表明，DMH的神经元在表达食物耐受的昼夜节律中具有关键作用。
Circadian rhythms of behavior and physiology can be entrained by daily cycles of restricted food availability, but the pathways that mediate food entrainment are unknown. The dorsomedial hypothalamic nucleus (DMH) is critical for the expression of circadian rhythms and receives input from systems that monitor food availability. Here we report that restricted feeding synchronized the daily rhythm of DMH activity in rats such that c-Fos expression in the DMH was highest at scheduled mealtime. During food restriction, unlesioned rats showed a marked preprandial rise in locomotor activity, body temperature and wakefulness, and these responses were blocked by cell-specific lesions in the DMH. Furthermore, the degree of food entrainment correlated with the number of remaining DMH neurons, and lesions in cell groups surrounding the DMH did not block entrainment by food. These results establish that the neurons of the DMH have a critical role in the expression of food-entrainable circadian rhythms.