Remodelling Ca2+ signalling systems and cardiac hypertrophy
Remodelling Ca2+ signalling systems and cardiac hypertrophy
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DOI：
10.1042/bst0340228
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发表时间：
2006-04-01
影响因子：
3.9
通讯作者：
Berridge, MJ
中科院分区：
文献类型：
--
作者：
Berridge, MJ
在心肌细胞中，Ca2+信号表现为负责控制收缩和转录的短暂瞬变。信息可以通过频率和形状的变化被编码在这些数字信号中。Ca2+信号传导的增加有助于肥大期间的表型重塑过程。Ca2+的增加，驱动较大的收缩可能是负责开关信号体重塑下调Ca2+信号通路的第二个过程。这是Ca2+瞬变特性的变化，其似乎携带负责心脏基因转录程序重塑的信息，该基因转录程序首先导致肥大，然后导致充血性心力衰竭。
In cardiac cells, Ca2+ signals appear as brief transients responsible for controlling both contraction and transcription. information may be encoded in these digital signals through changes in both frequency and shape. An increase in Ca2+ signalling contributes to a process of phenotypic remodelling during hypertrophy. The increase in Ca2+ that drives the larger contractions may be responsible for switching on a second process of signalosome remodelling to down-regulate the Ca2+ signalling pathway. it is a change in the properties of the Ca2+ transient that seems to carry the information responsible for the remodelling of the cardiac gene transcription programme that leads first to hypertrophy and then to congestive heart failure.