Development of teeth in chick embryos after mouse neural crest transplantations
Development of teeth in chick embryos after mouse neural crest transplantations
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DOI：
10.1073/pnas.1137104100
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发表时间：
2003-05-27
影响因子：
11.1
通讯作者：
Fontaine-Pérus, J
中科院分区：
文献类型：
--
作者：
Mitsiadis, TA;Chéraud, Y;Fontaine-Pérus, J
Teeth were lost in birds 70-80 million years ago. Current thinking holds that it is the avian cranial neural crest-derived mesenchyme that has lost odontogenic capacity, whereas the oral epithelium retains the signaling properties required to induce odontogenesis. To investigate the odontogenic capacity of ectomesenchyme, we have used neural tube transplantations from mice to chick embryos to replace the chick neural crest cell populations with mouse neural crest cells. The mouse/chick chimeras obtained show evidence of tooth formation showing that avian oral epithelium is able to induce a nonavian developmental program in mouse neural crest-derived mesenchymal cells.
