International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between eight high-income countries but similar rise during adolescence-A quality registry study
International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between eight high-income countries but similar rise during adolescence-A quality registry study
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DOI：
10.1111/pedi.13014
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发表时间：
2020-04-14
影响因子：
3.4
通讯作者：
Warner, Justin T.
中科院分区：
文献类型：
--
作者：
Anderzen, Johan;Hermann, Julia M.;Warner, Justin T.
研究目的：确定8个高收入国家儿童和青少年中HbA 1c水平和模式在年龄和性别方面的差异和相似性。受试者66 071名18岁以下儿童和青少年，患有1型糖尿病至少3个月，在研究期间至少测量过一次HbA 1c。方法：儿科糖尿病质量登记数据来自奥地利、丹麦、英国、德国、挪威、瑞典、美国、在2013年至2014年间收集的。HbA 1c，性别，年龄，和持续时间在analysis.Results的性别和年龄组的分布是相似的八个参与国。各国之间的平均HbA 1c为60 - 73 mmol/mol（7.6%-8.8%）。在所有国家，最年轻（0-9岁）至最年长（15-17岁）年龄组之间的HbA 1c增加接近8 mmol/mol（0.7%）（P < .001）。女性有1 mmol/mol（0.1%）高于平均HbA 1c比男孩（P <0.001）在七个八countries.Conclusions尽管国家之间的平均HbA 1c的巨大差异，一个显着的相似性HbA 1c从儿童期到青春期的增加被发现。
Objectives To identify differences and similarities in HbA1c levels and patterns regarding age and gender in eight high-income countries.Subjects 66 071 children and adolescents below18 years of age with type 1 diabetes for at least 3 months and at least one HbA1c measurement during the study period.Methods Pediatric Diabetes Quality Registry data from Austria, Denmark, England, Germany, Norway, Sweden, the United States, and Wales were collected between 2013 and 2014. HbA1c, gender, age, and duration were used in the analysis.Results Distribution of gender and age groups was similar in the eight participating countries. The mean HbA1c varied from 60 to 73 mmol/mol (7.6%-8.8%) between the countries. The increase in HbA1c between the youngest (0-9 years) to the oldest (15-17 years) age group was close to 8 mmol/mol (0.7%) in all countries (P < .001). Females had a 1 mmol/mol (0.1%) higher mean HbA1c than boys (P < .001) in seven out of eight countries.Conclusions In spite of large differences in the mean HbA1c between countries, a remarkable similarity in the increase of HbA1c from childhood to adolescence was found.