Observations on hydronephrosis after pig kidney transplantation in baboons.
Observations on hydronephrosis after pig kidney transplantation in baboons.
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DOI：
10.1111/xen.12779
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发表时间：
2022-11
影响因子：
3.9
通讯作者：
Cooper, David K. C.
中科院分区：
文献类型：
--
作者：
Foote, Jeremy B.;Bikhet, Mohamed H.;Hansen-Estruch, Christophe;Javed, Mariyam;Ayares, David;Hara, Hidetaka;Humar, Abhinav;Eckhoff, Devin E.;Cooper, David K. C.
我们在11只（21%）基因工程猪肾中的3只（21%）尸检时观察到肾积水（梗阻性肾病），这些肾在狒狒体内发挥作用超过36天，即使排斥反应的临床和组织病理学特征很小。我们简要报告一例，并说明这种肾脏和输尿管的宏观和微观外观。观察到的变化的原因仍然不确定。在我们的小经验中，肾积水的发展与（i）手术技术，（ii）猪的基因型，（iii）猪输尿管的长度，或（iv）免疫抑制和抗炎治疗之间似乎没有相关性。我们认为远端输尿管增厚可能是炎症反应的结果。在两个病例中，我们通过在近端猪输尿管和狒狒膀胱之间进行二次侧对侧吻合来解决问题。
We have seen hydronephrosis (obstructive nephropathy) at necropsy in 3 of 11 (21%) genetically-engineered pig kidneys that functioned in baboons for >36 days, even when the clinical and histopathological features of rejection were minimal. We briefly report one such case, and illustrate the macroscopic and microscopic appearances of such a kidney and ureter. The causes of the observed changes remain uncertain. In our small experience, there seems to be no correlation between the development of hydronephrosis and (i) the surgical technique, (ii) the genotype of the pig, (iii) the length of the pig ureter, or (iv) the immunosuppressive and anti-inflammatory therapy administered. We suggest that the distal ureteric thickening may be the result of an inflammatory response. In two cases, we resolved the problem by carrying out a secondary side-to-side anastomosis between the proximal pig ureter and the baboon bladder.
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