Rhythmic firing of medial septum non-cholinergic neurons
Rhythmic firing of medial septum non-cholinergic neurons
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DOI：
10.1016/0306-4522(96)00349-1
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发表时间：
1996-12-01
期刊：
影响因子：
3.3
通讯作者：
Muhlethaler, M
中科院分区：
文献类型：
--
作者：
Serafin, M;Williams, S;Muhlethaler, M
海马体中θ节律（3）（5-10 Hz）的存在已被证明能够实现长时程增强（12，18），这是一种被认为是学习和记忆基础的突触机制。已经假设投射到海马的内侧隔胆碱能和GABA能神经元（7、11、17、24、26、34）在这种节律的发生中共同起主要作用。（3，19，31）建立在先前的研究基础上，这些研究已经建立了区分该区域胆碱能和非胆碱能神经元的电生理学标准，（1，2，8，9，14，23）在此证明，内侧隔非胆碱能神经元（puronicGABA能神经元）具有以1至8 Hz频率发生的动作电位节律簇放电的能力。在簇内，动作电位的放电频率在13和57 Hz之间变化，呈电压依赖性。此外，小的电压依赖性阈下膜电位振荡（16-54 Hz）之间的集群观察。阈下振荡和集群仅仅消除河豚毒素在1 μ M。这些结果表明，非胆碱能内侧隔神经元不仅可以向海马传递θ波，而且还可以传递β-γ波范围内的高频节律性（20-60 Hz）。版权所有（C）1996 IBRO。
The presence of theta rhythm(3) (5-10 Hz) in the hippocampus has been shown to enable long-term potentiation,(12,18) a synaptic mechanism which has been proposed to underlie learning and memory. Medial septum cholinergic and GABAergic neurons that project to the hippocampus(7,11,17,24,26,34) have been hypothesized to play conjointly a major role in the genesis of this rhythm.(3,19,31) Building upon previous studies that have established the electrophysiological criteria for distinguishing cholinergic and non-cholinergic neurons in this area,(1,2,8,9,14,23) it is demonstrated here that medial septum non-cholinergic neurons, putatively GABAergic, have the ability to discharge in rhythmic clusters of action potentials occurring at frequencies ranging from 1 to 8 Hz. Within the clusters, the firing frequency of action potentials varied between 13 and 57 Hz in a voltage-dependent manner. In addition, small voltage-dependent subthreshold membrane potential oscillations (16-54 Hz) were observed between clusters. Both subthreshold oscillations and clusters mere eliminated by tetrodotoxin at 1 mu M. These results indicate that non-cholinergic medial septum neurons could convey to the hippocampus not only theta but also higher frequency rhythmicity in the beta-gamma range (20-60 Hz). Copyright (C) 1996 IBRO.