VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value
VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value
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DOI：
10.1007/s11255-008-9362-7
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发表时间：
2008-12-01
影响因子：
2
通讯作者：
Ozkardes, Hakan
中科院分区：
文献类型：
--
作者：
Dirim, Ayhan;Haberal, Asuman Nihan;Ozkardes, Hakan
旨在评估 VEGF（血管内皮生长因子）、COX-2（环氧合酶-2）和 PCNA（增殖细胞核抗原）等新标志物的预后价值，并回顾其在肾细胞癌 (RCC) 患者中按组织学亚型表达的差异。 本研究纳入了约 99 例接受根治性 (n = 79) 或部分肾切除术 (n = 20) 的患者。对受试者的组织病理学标本进行免疫组织化学回顾性分析，以确定 VEGF、COX-2 或 PCNA 的存在。VEGF、COX-2 和 PCNA 的平均染色率分别为 16.5%、16.8% 和 31%。评估这三个预后因素之间的相关性。 PCNA 和 VEGF 之间不存在相关性 (P = .068)，但 COX-2 与 PCNA 和 VEGF 之间存在显着相关性（分别为 P = .005 和 P = .000）。 VEGF 的表达与病理分期和血管侵犯之间存在显着相关性（分别为 P = .018 和 P = .025）。此外，常规 RCC 患者的 VEGF 和 COX-2 水平显着低于乳头状 RCC 患者 (P < .012)。很明显，VEGF、COX-2 和 PCNA 等预后因素可能因组织学亚型而异。这些因子的表达水平以及组织学亚型可以提供有关治疗结果的有价值的预测信息。
To evaluate the prognostic value of new markers such as VEGF (vascular endothelial growth factor), COX-2 (cyclooxygenase-2), and PCNA (proliferating cell nuclear antigen) and review their differences in expression by histological subtype in patients with renal cell carcinoma (RCC).About 99 patients who underwent radical (n = 79) or partial nephrectomy (n = 20) were included in this study. Histopathological specimens from the subjects were retrospectively analyzed immunohistochemically for the presence of VEGF, COX-2, or PCNA.Mean staining ratios for VEGF, COX-2, and PCNA were 16.5, 16.8, and 31%, respectively. Correlations were evaluated among these three prognostic factors. There was no correlation between PCNA and VEGF (P = .068), but there were significant correlations between COX-2 and both PCNA and VEGF (P = .005 and P = .000, respectively). A significant correlation was found between the expression of VEGF and both pathologic stage and vascular invasion (P = .018 and P = .025, respectively). In addition, patients with conventional RCC had significantly lower VEGF and COX-2 levels than those with papillary RCC (P < .012).It is obvious that prognostic factors such as VEGF, COX-2, and PCNA may vary depending on histological subtype. The level of expression of these factors together with histological subtype may provide valuable predictive information about the outcome of treatment.