Evaluation of a Web-based decision aid for people considering the APOE genetic test for Alzheimer risk
Evaluation of a Web-based decision aid for people considering the APOE genetic test for Alzheimer risk
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DOI：
10.1038/gim.2016.170
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发表时间：
2017-06-01
影响因子：
8.8
通讯作者：
Zallen, Doris T.
中科院分区：
文献类型：
--
作者：
Ekstract, Michael;Holtzman, Golde I.;Zallen, Doris T.
目的：随着人们对载脂蛋白E（APOE）基因检测的兴趣越来越大，以估计发生迟发性阿尔茨海默病的风险，需要新的教育工具来帮助人们做出最好的决定是否接受这项测试。本研究评估了一个在线工具，以协助在此决策process.Methods：一个原型的决策援助进行了研究，在两部分的调查，收集数据，从参与者之前和之后，他们检查的决策援助。这两项调查都有多项选择和开放式答复的机会，提供定量和定性信息。使用援助之前和之后的反应进行了比较each participator.Results：共有1,262人完成了这两项调查。决策辅助的总体有效性通过三个指标来显示：94%的人认为决策辅助非常有帮助或有点帮助;一般知识增加;一些人改变了对APOE基因检测的想法，35%的人转向接受测试的可能性更高，20%的人转向可能性更低。改进的建议被注意到，并纳入在线tools.Conclusion：这种决策援助可以提供有用的教育援助，许多人，因为他们认为APOE基因检测，以及促进与他们的医疗保健提供者进一步讨论。
Purpose: With the increasing interest in apolipoprotein E (APOE) genetic testing to estimate the risk of developing late-onset Alzheimer disease, new educational tools are needed to help people make the best decision for themselves about whether to undergo this test. This study evaluated an online tool to assist in this decision process.Methods: A prototype decision aid was studied in a two-part survey that collected data from participants before and after they examined the decision aid. Both surveys had multiple-choice options and opportunities for open-ended responses, yielding quantitative and qualitative information. The responses before and after use of the aid were compared for each participant.Results: A total of 1,262 individuals completed both surveys. The overall effectiveness of the decision aid was shown by three measures: 94% found the decision aid very helpful or somewhat helpful; general knowledge was increased; and some people changed their minds about APOE genetic testing, with 35% shifting to a higher likelihood of undergoing the test and 20% to a lower likelihood. Suggestions for improvements were noted and incorporated into the online tool.Conclusion: This decision aid can provide useful educational assistance to many individuals as they consider APOE genetic testing as well as facilitate further discussions with their health-care providers.