Factors associated with prognosis of upper limb function in branch atheromatous disease
Factors associated with prognosis of upper limb function in branch atheromatous disease
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DOI：
10.1016/j.clineuro.2022.107267
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发表时间：
2022-05-11
影响因子：
1.9
通讯作者：
Okita, Yuho
中科院分区：
文献类型：
--
作者：
Tokuda, Kazuhiro;Hanada, Keisuke;Okita, Yuho
背景资料：分支动脉粥样硬化病（BAD）常伴有皮质脊髓束损伤，有些患者在急性期出现早期神经功能恶化（END）。本研究旨在探讨急性期BAD后上肢功能预后的进展，并探讨影响上肢功能预后的相关因素。程序：纳入108例诊断为BAD的受试者。将受试者分为上肢功能恢复良好组和上肢功能恢复不良组。单因素和多因素分析的目标变量是良好或不良的上肢功能。以下因素被用作解释变量：年龄、梗死体积、初始Fugl-Meyer评估（FMA）上肢评分和是否存在END。主要发现：单因素分析显示年龄和梗死体积差异有统计学意义（p < 0.05）。多因素分析显示以下结果：年龄（OR 0.977，95%CI 0.917-0.997，p = 0.0061）;梗死体积（OR 0.645，95%CI 0.461-0.902，p = 0.0104）。在年龄和梗死体积上有显著差异。结论：本研究结果表明年龄和梗死体积与BAD上肢瘫痪的预后相关。
Background: Branch atheromatous disease (BAD) is often associated with corticospinal tract injury, and some patients develop early neurological deterioration (END) in the acute phase. This study investigated the progress of upper limb prognosis after BAD in the acute phases and examined the factors related to the prognosis of upper limb function. Procedures: 108 subjects diagnosed with BAD were included. Then subjects were classified into two groups: those with good recovery of upper limb function and those with poor recovery of upper limb function. Univariate and multivariate analyses were performed with the objective variable being good or poor upper limb function. The following factors were used as explanatory variables: age, the volume of infarction, initial Fugl-Meyer assessment (FMA) upper limb score, and presence of END. Main findings: The univariate analysis showed significant differences in age and volume of infarction (p < 0.05). Multivariate analysis showed the following finding: age;(OR 0.977,95%CI 0.917-0.997, p = 0.0061; volume of infarction;(OR 0.645,95%CI 0.461-0.902, p = 0.0104). A significant difference was found in the age and volume of the infarct. Conclusion: This study finding suggests that age and volume of infarction are associated with the prognosis of upper extremity paralysis in BAD.