The relationship between brown adipose tissue activity and neoplastic status: an (18)F-FDG PET/CT study in the tropics.
The relationship between brown adipose tissue activity and neoplastic status: an (18)F-FDG PET/CT study in the tropics.
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DOI：
10.1186/1476-511x-10-238
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发表时间：
2011-12-20
影响因子：
4.5
通讯作者：
Chiu NT
中科院分区：
文献类型：
--
作者：
Huang YC;Chen TB;Hsu CC;Li SH;Wang PW;Lee BF;Kuo CY;Chiu NT
棕色脂肪组织（BAT）具有产热潜能。对于其激活，冷暴露被认为是一个关键因素，尽管也有其他决定因素的报道。本研究的目的是通过2-脱氧-2-[18 F]氟-D-葡萄糖（18 F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）评估热带地区人群肿瘤状态与BAT活性之间的关系，热带地区的室外温度影响较低。审查18F-FDG PET/CT扫描，并对鉴定的活化BAT的总代谢活性（TMA）进行定量。在有和没有癌症病史的患者之间比较活化BAT的分布和TMA。根据患者的癌症病史和18F-FDG PET/CT结果对患者的肿瘤状态进行评分。我们评估了BAT的TMA和肿瘤状态沿着其他因素之间的关系：年龄、体重指数、空腹血糖、性别和室外温度。1740名患者中有30名激活了BAT。有癌症病史的患者BAT分布较宽（p = 0.043），TMA较高（p = 0.028）。较高的肿瘤状态评分与较高的平均TMA相关。多变量分析显示，肿瘤状态是与活化BAT的TMA显著相关的唯一因素（p = 0.016）。肿瘤状态是生活在热带地区的患者BAT活性的关键决定因素。更活跃的肿瘤状态与BAT的更活跃的TMA相关。
Brown adipose tissue (BAT) has thermogenic potential. For its activation, cold exposure is considered a critical factor though other determinants have also been reported. The purpose of this study was to assess the relationship between neoplastic status and BAT activity by 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in people living in the tropics, where the influence of outdoor temperature was low. 18F-FDG PET/CT scans were reviewed and the total metabolic activity (TMA) of identified activated BAT quantified. The distribution and TMA of activated BAT were compared between patients with and without a cancer history. The neoplastic status of patients was scored according to their cancer history and 18F-FDG PET/CT findings. We evaluated the relationships between the TMA of BAT and neoplastic status along with other factors: age, body mass index, fasting blood sugar, gender, and outdoor temperature. Thirty of 1740 patients had activated BAT. Those with a cancer history had wider BAT distribution (p = 0.043) and a higher TMA (p = 0.028) than those without. A higher neoplastic status score was associated with a higher average TMA. Multivariate analyses showed that neoplastic status was the only factor significantly associated with the TMA of activated BAT (p = 0.016). Neoplastic status is a critical determinant of BAT activity in patients living in the tropics. More active neoplastic status was associated with more vigorous TMA of BAT.