Possible growth hormone control of liver glutamine synthetase activity in rats.
Possible growth hormone control of liver glutamine synthetase activity in rats.
复制标题
生长激素可能控制大鼠肝脏谷氨酰胺合成酶活性。
DOI：
10.1210/endo-106-1-268
复制
发表时间：
1980
期刊：
影响因子：
4.8
通讯作者：
A. Dunn
中科院分区：
文献类型：
--
作者：
B. S. Wong;M. Chenoweth;A. Dunn
Hypophysectomy is followed by a decrease in glutamine synthetase activity in rat liver and kidney homogenates; brain enzyme activity is unchanged. A bovine GH regimen increases enzyme activity in the liver and kidney but not in the brain. Maintenance doses of cortisol given to hypophysectomized rats, either alone or in concert with GH, have no effect on glutamine synthetase activity. Glutamate dehydrogenase activity is decreased (∼20%) 2 months after hypophysectomy but not t o the same extent as glutamine synthetase (∼75%). GH has no effect on glutamate dehydrogenase, while cortisol increases the activity of this enzyme. These results suggest that the GH effect on glutamine synthetase activity is a specific action rather than part of a general stimulation of protein synthesis. Although the glutamine synthetase level in the liver is markedly lowered (∼75%) 2 months after hypophysectomy, its percent distribution among different cell fractions, its Michaelis constant for glutamate and hydroxylamine, and its ...
