Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor
Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor
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DOI：
10.1016/j.ejphar.2005.12.073
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发表时间：
2006-03-18
影响因子：
5
通讯作者：
Koyama, T
中科院分区：
文献类型：
--
作者：
Izumi, T;Inoue, T;Koyama, T
本研究旨在阐明选择性5-羟色胺再摄取抑制剂(SSRI)西酞普兰在大鼠条件恐惧应激(CFS)中发挥抗焦虑作用的脑区。采用免疫组织化学方法观察西酞普兰对CFS诱导的c-Fos表达的影响。西酞普兰全身给药可减弱CFS诱导的c-Fos在次级运动皮质、初级躯体感觉皮质和杏仁核基底外侧核的表达。在这些区域中，杏仁核的基底外侧核可能是西酞普兰发挥抗焦虑作用的候选区域。(C)2005 Elsevier B.V.保留所有权利。
The purpose of the present study was to elucidate the brain regions in which citalopram, a selective serotonin reuptake inhibitor (SSRI), exerts its anxiolytic effects in conditioned fear stress (CFS) in rats, an animal model of anxiety. The effect of citalopram on CFS-induced c-Fos expression was investigated using immunohistochemistry. Systemic administration of citalopram attenuated contextual CFS-induced c-Fos expression in the secondary motor cortex, primary somatosensory cortex, and basolateral nucleus of the amygdala. Among these regions the basolateral nucleus of the amygdala is a likely candidate region in which citalopram exerts its anxiolytic effect. (c) 2005 Elsevier B.V. All rights reserved.