Neuroimaging studies of the hippocampus in schizophrenia
Neuroimaging studies of the hippocampus in schizophrenia
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DOI：
10.1002/hipo.1068.abs
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Heckers, S
中科院分区：
文献类型：
--
作者：
Heckers, S
三种神经影像学技术，形态计量学神经影像学，磁共振波谱，和功能神经影像学，提供了证据，异常海马结构和功能的精神分裂症。海马体积减少现在是在精神分裂症中发现的最一致的结构异常之一：它存在于疾病发作时，并且在较小程度上存在于精神分裂症先证者的一级亲属中。N-乙酰天冬氨酸水平的降低指向这种体积变化的细胞基础。功能性神经影像学研究表明，在休息时，在幻听的经验，并在记忆检索任务的性能海马活动水平异常。这些神经影像学研究的结果补充了尸检和行为研究的证据，这些研究发现了精神分裂症患者海马体和记忆功能的区域特异性异常。(C)2001 Wiley-Liss，Inc.
Three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia. Hippocampal volume reduction is now one of the most consistent structural abnormalities found in schizophrenia: it is present at the onset of the illness and, to a lesser degree, in first-degree relatives of schizophrenic probands. Decreased levels of N-acetyl-aspartate point towards a cellular basis of such volume changes. Functional neuroimaging studies have demonstrated abnormal levels of hippocampal activity at rest, during the experience of auditory hallucinations, and during the performance of memory retrieval tasks. These results of neuroimaging studies complement evidence from post-mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia. (C) 2001 Wiley-Liss, Inc.