Effects of volume expansion on renal nerve activity, renal blood flow, and sodium and water excretion in conscious dogs.
Effects of volume expansion on renal nerve activity, renal blood flow, and sodium and water excretion in conscious dogs.
复制标题
扩容对清醒犬肾神经活动、肾血流量以及钠和水排泄的影响。
DOI：
10.1152/ajprenal.1985.249.5.f680
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Vatner,SF
中科院分区：
文献类型：
--
作者：
Morita,H;Vatner,SF
在清醒的狗中，检查了用等渗的3%右旋糖酐盐水溶液进行急性容量扩张对肾神经活动（RNA）、肾血流量、血管阻力以及钠和水排泄的影响。在完整犬中，急性容量扩张使平均动脉压升高15 +/- 3 mmHg，左心房压升高5.5 +/- 0.6 mmHg，RNA降低88 +/-2%，而肾血流量未发生变化，肾血管阻力略有增加。当肾灌注压维持在对照水平时，体积扩张使RNA降低87 +/- 2%，肾血管阻力降低15 +/-4%。在容量扩张后的80分钟内，尿流率增加0.66 +/- 0.13 ml/min，钠排泄增加3.89 +/- 0.54 mueq X min-1 X kg-1，而RNA仍然受到抑制。动脉压力感受器去神经（ABD）并没有减少RNA，肾血流量，肾血管阻力，或钠和水排泄量的反应，以扩大容量。ABD加双侧颈迷走神经切断术后，容量扩张并没有减少RNA，利尿和利钠反应明显减弱（P <0.025）。然而，肾血流对体积扩张的反应没有显著改变。在清醒的去肾神经犬中，肾血流对容量扩张的反应没有受损，而利尿和利钠反应减弱（P <0.025）。因此，在完整的清醒狗，迷走神经介导的反射减少RNA诱导的急性容量扩张产生显着影响钠和水的排泄，但很少控制肾血流量和肾血管阻力。
Effects of acute volume expansion with isotonic isoncotic 3% dextran in saline were examined on renal nerve activity (RNA), renal blood flow, vascular resistance, and sodium and water excretion in conscious dogs. In intact dogs, acute volume expansion increased mean arterial pressure 15 +/- 3 mmHg, left atrial pressure 5.5 +/- 0.6 mmHg, and decreased RNA 88 +/- 2%, whereas renal blood flow did not change and renal vascular resistance increased slightly. When renal perfusion pressure was maintained at control levels, volume expansion decreased RNA 87 +/- 2% and renal vascular resistance 15 +/- 4%. During the 80-min period after volume expansion, urine flow rate increased 0.66 +/- 0.13 ml/min and sodium excretion rose 3.89 +/- 0.54 mueq X min-1 X kg-1, whereas RNA remained depressed. Arterial baroreceptor denervation (ABD) did not diminish responses of RNA, renal blood flow, renal vascular resistance, or sodium and water excretion to volume expansion. After ABD plus bilateral cervical vagotomy, volume expansion did not decrease RNA, and diuretic and natriuretic responses were significantly attenuated (P less than 0.025). However, responses of renal blood flow to volume expansion were not altered significantly. In conscious dogs with renal denervation, responses of renal blood flow to volume expansion were not impaired, whereas diuretic and natriuretic responses were attenuated (P less than 0.025). Thus, in intact conscious dogs, vagally mediated reflex decreases in RNA induced by acute volume expansion exerted a significant effect on sodium and water excretion but little control of renal blood flow and renal vascular resistance.